Li¡VTsai, is a important person of the rationalism in the Middle and late Ming Dynasty. After middle Ming Dynasty, conscience lost the practice of the early aims. People to save the drawback of the Wang's descendants, have filed a new theory to correct the decadent atmosphere, one of the governance drawback of the descendants is the Substance of Nature to be raised. They not only integrate of both Chu's and Wang's though, also according to personal thinking of moral theories to breakthrough the new and review Wang's criterion, also to breakthrough Chu's doctrine system of limitations. Transfer of the Substance of Nature ideologue on the moral principles to chien¡V lo establishing leave Wang's category, appear to the moral theories by the Substance of Mind were turned to Substance of Nature of the rationalism in the late Ming Dynasty, and reflect the complex intertwined politics and society of the current situation and academic thought depravity seeking new response of Late Ming Dynasty. chien¡V lo according to Great Learning propose the doctrine of chih ¡V hsiu, mind¡Bconscience of Wang's though are classified as acquired,and classified the mind as Substance of Nature headed by the system. Unlike Wang's study of mind, is the ontological basis and cause Tong¡VLin resonance for the rescue Wang's correction movement in the positive direction of the late Ming Dynasty.The scholar of Substance of Nature headed are integrate of both Chu's and Wang's though , relies their own thinking of the founding the current situation and academic atmosphere to a new way, and, indirectly, reflect the pulse of the academic atmosphere of the Late Ming Dynasty. Li chien¡V lo stand in it , the chih¡Vhsiu theory has its leading role in the academic trend of the late Ming.