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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

Synthesis of (S,R,S)- and (R,S,R)-1,4,5,8,9,16- hexahydroxytetraphenylenes. / CUHK electronic theses & dissertations collection

January 2006 (has links)
*Please refer to dissertation for diagrams. / In addition, a precursor of tetraphenylene-based monodentate ligand ( S,S)-114 was also prepared, and the structures of five compounds, namely 89, 124, 125, 133 and 137 were examined by X-ray crystallographic analysis. These structural determinations were relevant in establishing regiochemistry and absolute stereochemistry.* / In the synthesis of enantiopure (S,R,S)-48 and (R,S,R)-48, two routes were successfully employed. One way was to follow the same pathway for the synthesis of racemic 48 by using enantiopure (S,S)- and (R,R)-1,8,9,16-teramethoxytetraphenylenes [(S,S)-89 and (R,R)- 89] as staring materials. Another way was by direct resolution of racemic 48 via derivatization into its two diastereomeric hexakis-(S)-camphorsulfonates 135 and 136. / In the synthesis of racemic 48, 3-nitrophenol (115) was employed as the starting material which upon a series of standard reactions provided 2,2'-diiodo-1,1'-biphenyl (119). Through sequential lithium-iodine exchange and Cu(II)-mediated oxidative cyclocoupling, 119 was converted to 1,8,9,16-tetramethoxytetraphenylene (89) . The key intermediate 1,8-dihydroxy-9,16-dimethoxytetraphenylene (87) was obtained by partial demethylation of 89. This intermediate was transformed to 1,4,5,8-tetrahydroxy-9,16-dimethoxytetraphenylene (126) by a quinone-hydroquinone strategy. Demethylation of 126 furnished the target compound 48. / This thesis describes the synthesis of 1,4,5,8,9,16-hexahydroxytetraphenylene (48)* in its racemic and enantiopure (S,R,S) and ( R,S,R) forms. Some essential background and previous works in this area are presented in the first chapter. / Wu Anhui. / "August 2006." / Adviser: Henry N. C. Wong. / Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1649. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2006. / Includes bibliographical references (p. 80-85). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese. / School code: 1307.
22

Stereo-selective binding of enantiomeric ligands in PPAR[gamma] : a molecular modeling study

Guo, Guanlun 01 January 2013 (has links)
No description available.
23

Structure-activity relationships and thermodynamics of combretastatin A-4 and A-1 derivatives as potential inhibitors of tubulin polymerization

Mugabe, Benon E. Trawick, Mary Lynn. January 2005 (has links)
Thesis (Ph.D.)--Baylor University, 2005. / Includes bibliographical references (p. 259-273).
24

Chemical-scale studies of ligand-gated ion channels

McMenimen, Kathryn Anna. Dougherty, Dennis A., Dervan, Peter B., January 1900 (has links)
Thesis (Ph. D.) -- California Institute of Technology, 2010. / Title from home page (viewed 03/04/2010). Advisor and committee chair names found in the thesis' metadata record in the digital repository. Includes bibliographical references.
25

SELEX: a tool to study the sequence specific molecular recognition of single stranded nucleic acids

Manimala, Joseph Chacko 28 August 2008 (has links)
Not available / text
26

Force and bond lifetime relationship of the P-selectin/PSGL-1 interaction

Marshall, Bryan 05 1900 (has links)
No description available.
27

Measuring ligand diffusivity and receptor binding kinetics within a cell membrane contact area

Tolentino, Timothy P. 05 1900 (has links)
No description available.
28

Human GM-CSF, IL-3 and IL-5 receptor expression and their functional domains studied with monoclonal antibodies / Qiyu Sun.

Sun, Qiyu January 1997 (has links)
Bibliography: leaves 123-141. / xv, 141 leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / This thesis developes specific tools to monitor receptor expression in a ligand-independent manner, demonstrates the receptor expression is not static and can be modulated by cytokines, identifies strong evidence in defining the N-terminal domain of IL-3R & chain and B'C' and F'G' loopes of domain 4 of Bc as functional domains involved in ligand binding and function and provides novel potential therapeutics. / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1997
29

Syntheses and coordination studies of [9]aneN3 substituted with increasing numbers of 2-hydroxyethyl pendant arms / Steffen Phillip Creaser.

Creaser, Steffen Phillip January 1999 (has links)
Copies of author's previously published articles inserted. / Bibliography: leaves 176-187. / xiii, 187 leaves ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Describes the syntheses of three 1,4,7-triazayclonane macrocyclic ligands functionalised with increasing numbers of 2-hydroxyethyl pendant arms. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 1999
30

Characterizing the extracellular domains of the relaxin and INSL3 receptors, LGR7 and LGR8 /

Scott, Daniel James. January 2006 (has links)
Thesis (Ph.D.)--University of Melbourne, Howard Florey Institute, Dept. of Biochemistry and Molecular Biology, 2007. / Typescript. Includes bibliographical references (leaves 179-185).

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