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Synthesis of (S,R,S)- and (R,S,R)-1,4,5,8,9,16- hexahydroxytetraphenylenes. / CUHK electronic theses & dissertations collectionJanuary 2006 (has links)
*Please refer to dissertation for diagrams. / In addition, a precursor of tetraphenylene-based monodentate ligand ( S,S)-114 was also prepared, and the structures of five compounds, namely 89, 124, 125, 133 and 137 were examined by X-ray crystallographic analysis. These structural determinations were relevant in establishing regiochemistry and absolute stereochemistry.* / In the synthesis of enantiopure (S,R,S)-48 and (R,S,R)-48, two routes were successfully employed. One way was to follow the same pathway for the synthesis of racemic 48 by using enantiopure (S,S)- and (R,R)-1,8,9,16-teramethoxytetraphenylenes [(S,S)-89 and (R,R)- 89] as staring materials. Another way was by direct resolution of racemic 48 via derivatization into its two diastereomeric hexakis-(S)-camphorsulfonates 135 and 136. / In the synthesis of racemic 48, 3-nitrophenol (115) was employed as the starting material which upon a series of standard reactions provided 2,2'-diiodo-1,1'-biphenyl (119). Through sequential lithium-iodine exchange and Cu(II)-mediated oxidative cyclocoupling, 119 was converted to 1,8,9,16-tetramethoxytetraphenylene (89) . The key intermediate 1,8-dihydroxy-9,16-dimethoxytetraphenylene (87) was obtained by partial demethylation of 89. This intermediate was transformed to 1,4,5,8-tetrahydroxy-9,16-dimethoxytetraphenylene (126) by a quinone-hydroquinone strategy. Demethylation of 126 furnished the target compound 48. / This thesis describes the synthesis of 1,4,5,8,9,16-hexahydroxytetraphenylene (48)* in its racemic and enantiopure (S,R,S) and ( R,S,R) forms. Some essential background and previous works in this area are presented in the first chapter. / Wu Anhui. / "August 2006." / Adviser: Henry N. C. Wong. / Source: Dissertation Abstracts International, Volume: 68-03, Section: B, page: 1649. / Thesis (Ph.D.)--Chinese University of Hong Kong, 2006. / Includes bibliographical references (p. 80-85). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Electronic reproduction. [Ann Arbor, MI] : ProQuest Information and Learning, [200-] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Abstracts in English and Chinese. / School code: 1307.
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Stereo-selective binding of enantiomeric ligands in PPAR[gamma] : a molecular modeling studyGuo, Guanlun 01 January 2013 (has links)
No description available.
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Structure-activity relationships and thermodynamics of combretastatin A-4 and A-1 derivatives as potential inhibitors of tubulin polymerizationMugabe, Benon E. Trawick, Mary Lynn. January 2005 (has links)
Thesis (Ph.D.)--Baylor University, 2005. / Includes bibliographical references (p. 259-273).
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Chemical-scale studies of ligand-gated ion channelsMcMenimen, Kathryn Anna. Dougherty, Dennis A., Dervan, Peter B., January 1900 (has links)
Thesis (Ph. D.) -- California Institute of Technology, 2010. / Title from home page (viewed 03/04/2010). Advisor and committee chair names found in the thesis' metadata record in the digital repository. Includes bibliographical references.
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SELEX: a tool to study the sequence specific molecular recognition of single stranded nucleic acidsManimala, Joseph Chacko 28 August 2008 (has links)
Not available / text
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Force and bond lifetime relationship of the P-selectin/PSGL-1 interactionMarshall, Bryan 05 1900 (has links)
No description available.
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Measuring ligand diffusivity and receptor binding kinetics within a cell membrane contact areaTolentino, Timothy P. 05 1900 (has links)
No description available.
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Human GM-CSF, IL-3 and IL-5 receptor expression and their functional domains studied with monoclonal antibodies / Qiyu Sun.Sun, Qiyu January 1997 (has links)
Bibliography: leaves 123-141. / xv, 141 leaves : ill. (some col.) ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / This thesis developes specific tools to monitor receptor expression in a ligand-independent manner, demonstrates the receptor expression is not static and can be modulated by cytokines, identifies strong evidence in defining the N-terminal domain of IL-3R & chain and B'C' and F'G' loopes of domain 4 of Bc as functional domains involved in ligand binding and function and provides novel potential therapeutics. / Thesis (Ph.D.)--University of Adelaide, Dept. of Medicine, 1997
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Syntheses and coordination studies of [9]aneN3 substituted with increasing numbers of 2-hydroxyethyl pendant arms / Steffen Phillip Creaser.Creaser, Steffen Phillip January 1999 (has links)
Copies of author's previously published articles inserted. / Bibliography: leaves 176-187. / xiii, 187 leaves ; 30 cm. / Title page, contents and abstract only. The complete thesis in print form is available from the University Library. / Describes the syntheses of three 1,4,7-triazayclonane macrocyclic ligands functionalised with increasing numbers of 2-hydroxyethyl pendant arms. / Thesis (Ph.D.)--University of Adelaide, Dept. of Chemistry, 1999
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Characterizing the extracellular domains of the relaxin and INSL3 receptors, LGR7 and LGR8 /Scott, Daniel James. January 2006 (has links)
Thesis (Ph.D.)--University of Melbourne, Howard Florey Institute, Dept. of Biochemistry and Molecular Biology, 2007. / Typescript. Includes bibliographical references (leaves 179-185).
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