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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
521

Crosslinked microspheres as drug delivery system for liver cancer

Nguyen, Thi Lam Uyen Nguyen, Centre for Advanced Macromolecular Design, Faculty of Engineering, UNSW January 2008 (has links)
It has been demonstrated that 1,25 dihydroxy vitamin D3 (1,25 (OH)2VD3) can inhibit the proliferation of cancer cells including colorectal and hepatocellular cells which are mainly responsible for liver cancer. However, the use of 1, 25 (OH)2VD3 is hampered due to the development of hypercalcaemia. Current treatment using hepatic arterial delivery of drug solution is inconvenient since repetitive invasive treatments are required. This work aims to tackle this problem by utilizing crosslinked microspheres prepared by suspension polymerization as a carrier to control the release of 1, 25 (OH)2VD3 or hydrophobic drug in general at targeted sites over a long period. Poly(vinyl neodecanoate crosslinked ethyleneglycol dimethacrylate) microspheres in the size range of 35 m were prepared via suspension polymerization. Different parameters in suspension polymerization such as temperature, concentration and crosslinker percentage were studied in details. The effect of stabilizer on the formation of spheres was carefully investigated by using RAFT polymerization to produce various structures of the stabilizer, poly (vinyl pyrrolidone). Core- shell microspheres were also produced to enhance the hydrophilicity of the surface of microspheres. Hydrophobic drugs were loaded to these microspheres after reaction by the evaporation method. These microspheres were then used for drug loading and drug release study. Release study has shown that up to 10% of drug was released after 40 days. Cytotoxicity test reveals the suitability of this polymer for application in biomedical field. The MTT assay of Clofazimine loaded microspheres on the colorectal cancer cell lines HT29 has shown that the cell number was decreased about 50% after drug treatment.
522

Comparative profiling of circulatory levels of adipokines and cytokines in patients with various types of non alcoholic fatty liver disease

Jarrar, Mohammed Hussein. January 2007 (has links)
Thesis (Ph. D.)--George Mason University, 2007. / Title from PDF t.p. (viewed Jan. 18, 2008). Thesis director: Ancha Baranova Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Biosciences. Vita: p. 213 Includes bibliographical references (p. 188-212). Also available in print.
523

Anti-fibrogenic effect of traditional Chinese Medicine 319 recipe

Cheung, Kwok-fan, Stephen, January 2007 (has links)
Thesis (M. Phil.)--University of Hong Kong, 2008. / Also available in print.
524

Investigations into mechanisms of paracetamol-induced toxicity using ìn vitro' systems /

Bruschi, Sam A. January 1987 (has links) (PDF)
Thesis (Ph. D.)--University of Adelaide, 1989. / Includes bibliographical references (leaves 116-138).
525

The effect of short-term pretreatment with peroxisome proliferators on the acute toxicity of various toxicants, including paracetamol /

Nicholls-Grzemski, Felicity April. January 1998 (has links) (PDF)
Thesis (Ph.D.)--University of Adelaide, Dept. of Clinical and Experimental Pharmacology, 1999. / Erratum tipped in before chapter 1. Bibliography: leaves 226-248.
526

Measurement, modelling and potential clinical applications of spatial variations in magnetic resonance proton transverse relaxation rates in iron-loaded liver and heart tissue /

Pontré, Beau. January 2006 (has links)
Thesis (Ph.D.)--University of Western Australia, 2006.
527

Investigation of portal vein bloodflow in cirrhotic portal hypertiension using computer-based and physical modelling methods

Petkova, Svetla Bogomilova. January 2008 (has links)
Thesis (PhD) - Swinburne University of Technology, 2008. / Submitted for the degree of Doctor of Philosophy, Swinburne University of Technology - 2008. Typescript. Includes bibliographical references (p.271-304).
528

[(Methyl)1-^11C]-Acetate Metabolism in Hepatocellular Carcinoma

Salem, Nicolas January 2009 (has links)
Thesis (Ph.D.)--Case Western Reserve University, 2009 / Abstract Department of Biomedical Engineering Title from OhioLINK (viewed on 20 April 2009) Available online via the OhioLINK ETD Center
529

Expression significance and functional characterization of homeoprotein Six 1 in hepatocellular carcinoma

Ng, Tak-pan. January 2008 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2008. / Includes bibliographical references (leaves 142-158) Also available in print.
530

In vivo and in vitro studies on the regulation of C-KI-RAS expression in liver /

Chan, Sai-on. January 1900 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1992.

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