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Characterization of novel tumor suppressor genes, DLC-1 and DLC-2, in hepatocellular carcinomaWong, Chun-ming, 黃俊銘 January 2003 (has links)
published_or_final_version / abstract / toc / Pathology / Doctoral / Doctor of Philosophy
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Crosslinked microspheres as drug delivery system for liver cancerNguyen, Thi Lam Uyen Nguyen, Centre for Advanced Macromolecular Design, Faculty of Engineering, UNSW January 2008 (has links)
It has been demonstrated that 1,25 dihydroxy vitamin D3 (1,25 (OH)2VD3) can inhibit the proliferation of cancer cells including colorectal and hepatocellular cells which are mainly responsible for liver cancer. However, the use of 1, 25 (OH)2VD3 is hampered due to the development of hypercalcaemia. Current treatment using hepatic arterial delivery of drug solution is inconvenient since repetitive invasive treatments are required. This work aims to tackle this problem by utilizing crosslinked microspheres prepared by suspension polymerization as a carrier to control the release of 1, 25 (OH)2VD3 or hydrophobic drug in general at targeted sites over a long period. Poly(vinyl neodecanoate crosslinked ethyleneglycol dimethacrylate) microspheres in the size range of 35 m were prepared via suspension polymerization. Different parameters in suspension polymerization such as temperature, concentration and crosslinker percentage were studied in details. The effect of stabilizer on the formation of spheres was carefully investigated by using RAFT polymerization to produce various structures of the stabilizer, poly (vinyl pyrrolidone). Core- shell microspheres were also produced to enhance the hydrophilicity of the surface of microspheres. Hydrophobic drugs were loaded to these microspheres after reaction by the evaporation method. These microspheres were then used for drug loading and drug release study. Release study has shown that up to 10% of drug was released after 40 days. Cytotoxicity test reveals the suitability of this polymer for application in biomedical field. The MTT assay of Clofazimine loaded microspheres on the colorectal cancer cell lines HT29 has shown that the cell number was decreased about 50% after drug treatment.
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Crosslinked microspheres as drug delivery system for liver cancerNguyen, Thi Lam Uyen Nguyen, Centre for Advanced Macromolecular Design, Faculty of Engineering, UNSW January 2008 (has links)
It has been demonstrated that 1,25 dihydroxy vitamin D3 (1,25 (OH)2VD3) can inhibit the proliferation of cancer cells including colorectal and hepatocellular cells which are mainly responsible for liver cancer. However, the use of 1, 25 (OH)2VD3 is hampered due to the development of hypercalcaemia. Current treatment using hepatic arterial delivery of drug solution is inconvenient since repetitive invasive treatments are required. This work aims to tackle this problem by utilizing crosslinked microspheres prepared by suspension polymerization as a carrier to control the release of 1, 25 (OH)2VD3 or hydrophobic drug in general at targeted sites over a long period. Poly(vinyl neodecanoate crosslinked ethyleneglycol dimethacrylate) microspheres in the size range of 35 m were prepared via suspension polymerization. Different parameters in suspension polymerization such as temperature, concentration and crosslinker percentage were studied in details. The effect of stabilizer on the formation of spheres was carefully investigated by using RAFT polymerization to produce various structures of the stabilizer, poly (vinyl pyrrolidone). Core- shell microspheres were also produced to enhance the hydrophilicity of the surface of microspheres. Hydrophobic drugs were loaded to these microspheres after reaction by the evaporation method. These microspheres were then used for drug loading and drug release study. Release study has shown that up to 10% of drug was released after 40 days. Cytotoxicity test reveals the suitability of this polymer for application in biomedical field. The MTT assay of Clofazimine loaded microspheres on the colorectal cancer cell lines HT29 has shown that the cell number was decreased about 50% after drug treatment.
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Expression significance and functional characterization of homeoprotein Six 1 in hepatocellular carcinomaNg, Tak-pan. January 2008 (has links)
Thesis (Ph. D.)--University of Hong Kong, 2008. / Includes bibliographical references (leaves 142-158) Also available in print.
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MT1-MMP in relation to metastasis of hepatocellular carcinomaIp, Ying-chi., 葉瑩芝. January 2005 (has links)
published_or_final_version / abstract / Surgery / Doctoral / Doctor of Philosophy
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Molecular study of the deleted in liver cancer 2 (DLC2)h[electronic resource]: solution structure of the SAM domain and interaction withMCM7Fung, King-leung., 馮景良. January 2005 (has links)
published_or_final_version / abstract / Chemistry / Doctoral / Doctor of Philosophy
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Identification and characterization of key genes involved in the development and progression of hepatocellular carcinomaLau, Sze-hang, Billy, 劉思行 January 2007 (has links)
published_or_final_version / abstract / Clinical Oncology / Doctoral / Doctor of Philosophy
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Blockade of chemokine (C-X-C motif) receptor 4 for the inhibition of hepatocellular carcinoma metastasisKok, Tsz-wai., 郭梓瑋. January 2008 (has links)
published_or_final_version / Surgery / Doctoral / Doctor of Philosophy
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Prognostic significance of circulating vascular endothlial [sic] growth factor in patients with hepatocellular carcinomaPoon, Tung-ping, Ronnie., 潘冬平. January 2006 (has links)
published_or_final_version / abstract / Surgery / Doctoral / Doctor of Philosophy
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Functional characterization of liver intestine-cadherin (CDH17) in hepatocellular carcinomaChan, Wai-man, Vivian, 陳慧雯 January 2006 (has links)
published_or_final_version / abstract / Surgery / Master / Master of Philosophy
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