This study use regional development and input-output analysis investigates Luchu Base¡¦s industries in the development and operation period that impact of the southern regional. The multipliers and impact analysis was performed through regional input-output analysis for Luchu Base. The publishment of Taiwan regional input-output table has been stopped since 1981. Therefore, this study estimate the southern regional input coefficient table for year 2001 using Mathematic process Method and Location Quotient Method. Then using this input coefficient table to forecast the changes of output and employment in the southern region and each prefecture or city after Luchu Base established. Finally, this study evaluates the future development of Luchu Base for regional economy. The major finding include, the key effected industries during the development period of Luchu Base which are construction correlation industries would be fabricated metal products, non-metallic mineral products, iron and steel industries, and electronic machinery and other electronic equipments industries. In operation period, the significantly economical effects industries will be Luchu Base¡¦s planning industries that are electronic products, other industrial products, and other chemical products; especially the most output effect is electronic products industry. The significantly economical effects are finance and insurance, and trade and retail industries. The establishment of Luchu Base tends to have positively economical effects for southern region in the development and operation period.