The current work deals with modelling longitudinal or repeated non-Gaussian measurements for a respiratory disease. The analysis of longitudinal data for non-Gaussian binary disease outcome data can broadly be modeled using three different approaches; the marginal, random effects and transition models. The marginal type model is used if one is interested in estimating population averaged effects such as whether a treatment works or not on an average individual. On the other hand random effects models are important if apart from measuring population averaged effects a researcher is also interested in subject specific effects. In this case to get marginal effects from the subject-specific model we integrate out the random effects. Transition models are also called conditional models as a general term. Thus all the three types of models are important in understanding the effects of covariates and disease progression and distribution of outcomes in a population. In the current work the three models have been researched on and fitted to data. The random effects or subject-specific model is further modified to relax the assumption that the random effects should be strictly normal. This leads to the so called hierarchical generalized linear model (HGLM) based on the h-likelihood formulation suggested by Lee and Nelder (1996). The marginal model was fitted using generalized estimating equations (GEE) using PROC GENMOD in SAS. The random effects model was fitted using PROC GLIMMIX and PROC NLMIXED in SAS (generalized linear mixed model). The latter approach was found to be more flexible except for the need of specifying initial parameter values. The transition model was used to capture the dependence between outcomes in particular the dependence of the current response or outcome on the previous response and fitted using PROC GENMOD. The HGLM was fitted using the GENSTAT software. Longitudinal disease outcome data can provide real and reliable data to model disease progression in the sense that it can be used to estimate important disease i parameters such as prevalence, incidence and others such as the force of infection. Problem associated with longitudinal data include loss of information due to loss to follow up such as dropout and missing data in general. In some cases cross-sectional data can be used to find the required estimates but longitudinal data is more efficient but may require more time, effort and cost to collect. However the successful estimation of a given parameter or function depends on the availability of the relevant data for it. It is sometimes impossible to estimate a parameter of interest if the data cannot its estimation. / Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2011.

Longitudinal data tend to be correlated and hence posing a challenge in the analysis since the correlation has to be accounted for to obtain valid inference. We study various statistical methods for such correlated longitudinal binary responses. These models can be grouped into five model families, namely, marginal, subject-specific, transition, joint and semi-parametric models. Each one of the models has its own strengths and weaknesses. Application of these models is carried out by analyzing data on patient’s adherence status to highly active antiretroviral therapy (HAART). One other complicating issue with the HAART adherence data is missingness. Although some of the models are flexible in handling missing data, they make certain assumptions about missing data mechanisms, the most restrictive being missing completely at random (MCAR). The test for MCAR revealed that dropout did not depend on the previous outcome. A logistic regression model was used to identify predictors for the patients’ first month’s adherence status. A marginal model was then fitted using generalized estimating equations (GEE) to identify predictors of long-term HAART adherence. This provided marginal population-based estimates, which are important for public health perspective. We further explored the subject’s specific effects that are unique to a particular individual by fitting a generalized linear mixed model (GLMM). The GLMM was also used to assess the association structure of the data. To assess whether the current optimal adherence status of a patient depended on the previous adherence measurements (history) in addition to the explanatory variables, a transition model was fitted. Moreover, a joint modeling approach was used to investigate the joint effect of the predictor variables on both HAART adherence status of patients and duration between successive visits. Assessing the association between the two outcomes was also of interest. Furthermore, longitudinal trajectories of observed data may be very complex especially when dealing with practical applications and as such, parametric statistical models may not be flexible enough to capture the main features of the longitudinal profiles, and so a semiparametric approach was adopted. Specifically, generalized additive mixed models were used to model the effect of time as well as interactions associated with time non-parametrically. / Thesis (Ph.D.)-University of KwaZulu-Natal, Pietermaritzburg, 2010.

Thesis (Ph.D.)--Tufts University, 1988. / Submitted to the Dept. of Child Study. Includes bibliographical references. Access restricted to members of the Tufts University community. Also available via the World Wide Web;

Diss. (sammanfattning) Uppsala : Uppsala universitet, 2006. / Härtill 5 uppsatser.

Thesis (Ph. D.)--University of Texas Health Science Center at Houston, School of Public Health, 2007. / Includes bibliographical references (leaves 58-59).

Thesis (Ed. D.)--University of Missouri-Columbia, 1996. / Typescript. Vita. Includes bibliographical references (leaves 131-136). Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 114-117). Also available on the Internet.

Thesis (Ph. D.)--University of Missouri-Columbia, 1997. / Typescript. Vita. Includes bibliographical references (leaves 114-117). Also available on the Internet.

Thesis (Ed. D.)--University of Missouri-Columbia, 1996. / Typescript. Vita. Includes bibliographical references (leaves 131-136). Also available on the Internet.

Thesis (Ph. D.)--Ohio State University, 2005. / Title from first page of PDF file. Document formatted into pages; contains xiii, 108 p.; also includes graphics. Includes bibliographical references (p. 104-108). Available online via OhioLINK's ETD Center