Thesis--University of Florida. / Description based on print version record. Typescript. Vita. Includes bibliographical references (vol. 2, leaves 780-785).

Thesis (M.A.)--University of Missouri-Columbia, 2004. / Typescript. Includes bibliographical references. Also available on the Internet.

Thesis (Ph. D.)--University of North Texas, May, 2007. / Title from title page display. Includes bibliographical references.

Thesis (Ph. D.)--University of Texas at Austin, 2007. / Vita. Includes bibliographical references.

The research described in this thesis is an attempt to understand the changing nature of redundancy, chequered working lives and unemployment in modern Britain. It focuses in particular on the ways in which a specific group of industrial workers and their families have perceived, mediated and reacted to the upheavals redundancy has caused in their lives. Section I deals with the history of the research; the problems associated with qualitative work and argues the case for a critical neo- Veberian methodology, as opposed to a general reliance on neo-Marxist perspectives in sociology. Section II examines economic and social change in contemporary Britain, paying particular attention to the recent histories of B. S. C. and South Yorkshire. Section III analyses the various effects of redundancy and unemployment on the nation, the local area, the family and the individual and those factors which can assist in pro-active responses to job loss. Some suggestions for the development of a social-psychology of redundancy et alia are made. The main findings deal with the experiences of these families, which are discussed within a life course perspective and include an examination of the many variables which can influence people's behaviour in these situations such as: class; age; occupation; gender; and political and religious consciousness. Family level variables are critically important, in particular the differing degrees of equality within particular marriages and households. The final section makes a conscious effort to link together the 'public issues' and 'private troubles' of redundancy et; alia. These are qualitatively different from those of earlier periods in the Twentieth Century and provide a challenge to sociologists and policy makers, who have not come to terms with their impact. This research indicates that neo-Marxism cannot adequately explain these phenomena. Some suggestions are made for a Critical Humanism, drawing on the best of sociology's diverse images of the social world, as a means of understanding the macro and micro-social realities of redundancy, chequered working lives and unemployment in the 1930's.

Mitochondrial dysfunction causes moderate to profound hearing loss both in isolation and as a feature of multi-systemic mitochondrial disease. The m.1555A > G mitochondrial DNA (mtDNA) variant is associated with a predisposition to aminoglycoside ototoxicity and maternally inherited non-syndromic deafness. However, the reasons for the highly variable penetrance of the associated hearing loss have not yet been fully resolved. Aminoglycosides are a recognised modifier factor of the hearing loss, but cannot account for all hearing impaired carriers in multi-generational pedigrees, implicating additional co-segregating genetic factors. By identifying and characterising the c.3G > A SSBP1 variant as a nuclear modifier of m.1555A > G the work detailed in this thesis extends our understanding of mitochondrial-nuclear interactions in human disease. To ascertain the frequency of the m.1555A > G variant in patients with suspected mitochondrial hearing loss we surveyed the laboratories within the United Kingdom that undertake genetic testing for this variant. We determined that the variant was not found more frequently in patients with known hearing impairment providing further evidence that m.1555A > G does not cause hearing loss in isolation. These results strengthened the case for nuclear genetic modifiers as important contributors to m.1555A > G pathogenesis. We next identified a multi-generational family that transmitted the m.1555A > G variant with variable clinical penetrance of hearing loss. In addition, a cohort of sporadic individuals carrying m.1555A > G was used to test the hypothesis that a conserved genetic mechanism accounted for the phenotype in all carriers. To this effect, we undertook whole exome sequencing in selected familial and sporadic carriers of m.1555A > G, identifying a heterozygous start loss mutation in the core mtDNA replisome protein gene, SSBP1, that co-segregated with the m.1555A > G variant and the phenotype in the family. The SSBP1 variant lead to a perturbation of mtDNA metabolism, and was associated with multiple mtDNA deletions and mtDNA depletion in skeletal muscle. Fibroblasts from these patients also showed mitochondrial network fragmentation and reduced intra-mitochondrial protein synthesis in keeping with the co-existing m.1555A > G variant, leading to reduced proliferation rates under conditions of forced mitochondrial respiration. Our findings provide an explanation for the variable clinical penetrance of the disorder within these m.1555A > G carriers and highlight the importance of trans-acting modifiers in mitochondrial disease.

Orientador: Horácio Faig Leite. / Banca: João Batista César Neto / Banca: Raquel Guedes Fernandes Pires / Banca: Maria Aparecida Neves Jardini / Banca: Warley David Kerbauy / Resumo: O objetivo desse estudo foi avaliar o efeito do uso local de uma solução aquosa de risendronato de sódio (RS) em diferentes concentrações na inibição da perda óssea alveolar decorrente de periodontite experimental induzida em ratas. Os 48 animais foram divididos em 2 grupos constituídos por 24 animais: GD (dupla aplicação) e GU (única aplicação). Os dois grupos foram subdivididos em 8 subgrupos: R1 (duas aplicações de 0,125 mg de RS), R2 (duas aplicações de 0,25 mg de RS), R3 (duas aplicações de 0,5 mg de RS) e A1 (duas aplicações de água destilada); R4 (uma aplicação de 0,125 mg de RS), R5 (uma aplicação de 0,25 mg de RS), R6 (uma aplicação de 0,5 mg de RS) e A2 (uma aplicação de água destilada). Foi induzida a periodontite pela confecção de ligaduras ao redor dos primeiros molares inferiores direitos em todos os animais. Nos grupos A1 e A2, os molares contralaterais serviram de controles negativos (C1 e C2). A medicação foi aplicada aos 5 e 10 dias após indução da periodontite nos animais do GD, e nos animais do GU apenas aos 10 dias. Decorrente 15 dias os animais foram submetidos à eutanásia. Foram feitas análises histológica, histomorfométrica, imuno-histoquímica anti-osteocalcina e enzimo-histoquímica para TRAP (fosfatase ácida tartarato resistente). Os grupos que receberam RS exibiram maior volume trabecular da crista óssea remanescente que o controle significante estatísticamente, mas não foram observados diferenças entre os grupos tratados. A perda óssea alveolar foi menor nos grupos tratados com risendronato comparado com controle e foi dose-dependente. Os grupos que receberam a menor dose (R1 e R4) apresentaram menor perda óssea estatisticamente... (Resumo completo, clicar acesso eletrônico abaixo) / Abstract: The aim of this study was to evaluate the local use of an aqueous solution of sodium risendronate (RS) at different concentrations on the inhibition of alveolar bone loss caused by experimental periodontitis induced in rats. The 48 animals were divided into two groups consisting of 24 animals: GD (double application) and GU (one application). The two groups were subdivided into eight subgroups: A1 (two applications of 0.125 mg RS), R2 (two applications of 0.25 mg RS), R3 (two applications of 0.5 mg RS) and A1 (two applications of distilled water), and R4 (one application of 0.125 mg RS), R5 (one application of 0.25 mg RS), R6 (one application of 0.5 mg RS) and A2 (one applications with distilled water). Periodontitis was induced in first molars in all animals. In groups A1 and A2, the contralateral molars served as controls (C1 and C2). The medication was applied at 5 and 10 days after induction of periodontitis in animals of GD, and animals of GU only after 10 days. After 15 days the animals were euthanized. Analysis was performed on histological, histomorphometric, immunohistochemical antiosteocalcin and enzimohistochemical for TRAP (tartrate resistant acid phosphatase). The groups that received RS exhibited greater volume of trabecular bone crest that controlling statistically significant, but no differences were observed between treated groups. The alveolar bone loss was lower in treated groups compared with placebo and was dose-dependent. The groups that received the lowest dose (R1 and R4) showed statistically significant less bone loss than the intermediate dose (R2 and R5), which in turn exhibited lower rates compared with higher doses (R3 and R6). The two types of approaches, however, did not show statistical significance. The number of TRAP-positive cells was... (Complete abstract click electronic access below) / Doutor

This thesis describes a series of experiments both in solution systems and soil systems to study the precipitation of calcium carbonate in soils and the effects of the precipitation on soil pH after urea had been applied. (1) A gas bubbling system has been established which introduces ammonia at a steady rate to the reaction solution and keeps it equilibrated at 0.00484 atm partial pressure of carbon dioxide. (2) In a non-seeded system, the effects of calcium, urea, Mg (magnesium), P (phosphate), and DOC (water-dissolved organic matter) on the precipitation were examined individually and in various combinations. Calcite and vaterite were found in the 10 mM CaC1₂ solutions with and without the addition of urea. When the solutions contained Mg, P, and DOC, vaterite was not found. Aragonite was found in the reaction solution containing 5 mM Mg. In high initial concentration of P (5x10^-4 M) , the formation of calcium phosphate (amorphous by X-ray analysis) catalysed the formation of calcite. The effects of urea and Mg on the precipitation are negligible compared with the effects of P and DOC. (3) In a seeded system, 16 sets of experiments with four sizes of calcite-seeds were carried out to study the precipitation rate of calcium carbonate. This was described by the equation LR=-4.113±0.132 + 0.379±0.029 LWA + LSI where LR=log (precipitation rate, PR, in mole litre^-1 min^-1), LWA= log (newly formed calcium carbonate, g ml^-1), and LSI=log (degree of supersaturation of calcium carbonate, SI). (4) A wide range of concentrations of urea (0.05, 0.1, 0.3, 0.5, 0.7, and 1 M) were added to three soils (Beg., Uni., and VWH) with or without the addition of 5 per cent of calcite (10-15 μm) to establish a rate model for the precipitation of calcium carbonate in soils. The precipitation model (in logarithmic form) in soils is lnPR=-9.47±0.30 + lnK_SOIL + 0.379±0.029 InWA + InSI - 1686±703 P - 6.13±3.02 DOC + 3854±1775 (P DOC) where P and DOC are the concentrations in soil solutions, and lnK_SOIL is the effect of soils on the precipitation, which is - 1.98, 0.43, and -0.10 for Beg., Uni., and VWH soils respectively. The amount of newly formed calcium carbonate is about a third to a half of the amount of ammoniacal-N released by urea hydrolysis. It was able to reduce the increase of soil pH by more than 0.6 pH units in some circumstances.

Overcapacity is a self-reflexive, personal journey film that explores the filmmaker's exploration of his lifelong problem with obesity and health. The film follows his progress as he discusses his weight problem with his partner and parents as well as works with a personal trainer and doctor in an effort to affect a lifestyle change while also confronting issues that have led to and perpetuate his current health situation.

Lötz and Du Plessis sum up the problem at hand most succinctly in their stating that “the relevant question is whether electronic contracts of sale can fulfil the general, legal requirements for the conclusion of a valid contract, and also where and when such contracts are (deemed to be) concluded”.2 In light of this statement, consider the following schematic representation of all the parties and their relationships, as typically occurring during the electronic contracting process: This statement succinctly sums up a single aspect of this problem, the so-called “contracting phase”. Following the traditional thought pattern, all aspects leading up to the point of conclusion need to be assessed and critically discussed as a failing or miscommunication in any one of the traditional requirements for the conclusion of a valid contract may later in the contractual relationship affect consensus and thus conclusion. This second phase “remedies and liability” refers to the situation where consensus is defective for one or other reason stemming from a failure in the internet/network services offered by the Internet Service Provider. A practical example of this may be: A and D have concluded pre-contractual negotiations and stand on the brink of consensus. A has signed the agreement and has forwarded same to D by means of e-mail. As far as A is concerned, the contract is concluded and he/she makes arrangements to fulfil of his/her obligations. D does not receive the signed agreement from A due to a failure on the part of his/her Internet Service Provider (C) – the server crashed and as a result he/she has no knowledge of A’s acceptance. D therefore concludes a contract with a third party for the same goods that form the subject of the contract with A and performs in terms of same. In these circumstances A has suffered economic loss due to his/her preparation to perform alternatively, full performance in terms of a contract he/she believed to be concluded. It goes without saying that neither A nor D are responsible for the loss A has suffered. The obvious question is then who is responsible for A’s loss? This work aims to assess firstly, the nature and the scope of possible remedies available to A to redress his/her loss, and secondly, the extent to which the Internet Service Provider can be held responsible for the failure of the communication medium. These issues will be discussed against the backdrop of the general principles of the law of contract and their application to this new and integral component in economic transactions. / Dissertation (LLM)--University of Pretoria, 2013. / am2014 / Mercantile Law / unrestricted