Usability testing is a branch of usability engineering that focuses on analyzing and improving user interactions with computer systems. This testing technique has been used in different industries for years and has proven to be very useful in determining major issues with applications before they are released, however the use of this technique has been slow to gain widespread acceptance in testing health information systems. This study was designed to determine if a specific form of usability testing, Low-Cost Rapid Usability Testing, can be introduced as a standard part of the system development lifecycle (SDLC) for health information systems in a cost effective manner. To determine if this was possible a full cost-benefit analysis of Low-Cost Rapid Usability Testing was performed on a health information system, the BC Chronic Disease Management (CDM) Toolkit, tracking all of the costs involved in the testing process and comparing them against the possible costs that may have been incurred if this testing was not performed. It was found that by introducing this technique into the system development lifecycle to allow for earlier detection of errors in a health information system it is possible to achieve an estimated 36.5% to 78.5% cost saving compared to the impact of errors going undetected and causing a technology-induced error. Overall it was found that Low-Cost Rapid Usability Testing can be implemented in conjunction with other testing techniques in a cost effective manner to develop health information systems, and computer systems in general, which will have a lower incidence of technology-induced errors. / Graduate