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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

Validation of the 60-second chair rise as a measure of physical function in patients with non-small cell lung cancer

Pereira, Lucy. January 2008 (has links)
Yearly, 22, 200 Canadians are diagnosed with lung cancer, with 80-85% of the cases being non-small cell lung cancer (NSCLC). With diagnoses being predominantly in the advanced stages, prognosis is poor and quality of life (QoL) becomes the focus of treatment. The main symptom cachexia, issues a loss of strength and impacts on an important aspect of QoL, physical function. Physical function is predominately assessed subjectively. Lately performance-based measures are gaining in popularity. One performance measure, the chair rise test, has not been validated in the NSCLC population and was the objective of this study. / Subjects completed the chair rise test, 6MWT, hand grip, and the SF-36 pre and post chemotherapy. Evidence for construct and discriminant validity but not predictive validity was provided for the chair rise test. The 60-second chair rise may be too strenuous for persons with severe disability but a standardized timed-based chair rise test is needed.

A novel deformable phantom for 4D radiotherapy verification /

Margeanu, Monica. January 2007 (has links)
The goal of conformal radiation techniques is to improve local tumour control through dose escalation to target volumes while at the same time sparing surrounding healthy tissue. Respiratory motion is known to be the largest intra-fractional organ motion and the most significant source of uncertainty in treatment planning for chest lesions. A method to account for the effects of respiratory motion is to use four-dimensional radiotherapy. While analytical models are useful, it is essential that the motion problem in radiotherapy is addressed by both modeling as well as experimentally studies so that different obstacles can be overcome before clinical implementation of a motion compensation method. Validation of techniques aimed at measuring and minimizing the effects of respiratory motion require a realistic dynamic deformable phantom for use as a gold standard. In this work we present the design, construction, performance and deformable image registration of a novel breathing, tissue equivalent phantom with a deformable lung that can reproducibly emulate 3D non-isotropic lung deformations according to any real lung-like breathing pattern. The phantom consists of a Lucite cylinder filled with water containing a latex balloon stuffed with dampened natural sponges. The balloon is attached to a piston that mimics the human diaphragm. Nylon wires and Lucite beads, emulating vascular and bronchial bifurcations, were glued at various locations, uniformly throughout the sponges. The phantom is capable of simulating programmed irregular breathing patterns with varying periods and amplitudes. A deformable, tissue equivalent tumour, suitable for holding radiochromic film for dose measurements was embedded in the sponge. Experiments for 3D motion assessment, motion reproducibility as well as deformable image registration and validation are presented using the deformable phantom.

Apoptotic signaling in lung carcinoma cells with focus on mechanisms of radioresistance /

Ekedahl, Jessica, January 2003 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 5 uppsatser.

Molecular aspects of cellular radiosensitivity in small cell lung carcinoma /

Sirzén, Florin, January 1900 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst. / Härtill 5 uppsatser.

The risk of second primary lung carcinoma in breast cancer patients /

Prochazka, Michaela, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.

Mortality and morbidity in lead smelter workers with concomitant exposure to arsenic /

Lundström, Nils-Göran, January 2007 (has links)
Diss. (sammanfattning) Umeå : Univ., 2007. / Härtill 4 uppsatser.

The use of IGF-IR inhibitors in cancer therapy - a potential approach for sensitizing tumor cells to ionizing radiation /

Cosaceanu, Daria, January 2006 (has links)
Diss. (sammanfattning) Stockholm : Karolinska institutet, 2006. / Härtill 4 uppsatser.

4D Monte Carlo investigation of organ motion in radiotherapy for lung cancer

Heath, Emily. January 1900 (has links)
Thesis (Ph.D.). / Written for the Dept. of Physics. Title from title page of PDF (viewed 2008/05/09). Includes bibliographical references.

Identifying a role for TGF-beta signaling in breast cancer metastasis to the lungs /

Padua, David M. January 2008 (has links)
Thesis (Ph. D.)--Cornell University, August, 2008. / Vita. Includes bibliographical references (leaves 133-147).

The role of smoking status on postoperative complications and survival in lung cancer patients presenting to M.D. Anderson Cancer Center /

Merriman, Kelly Willis. Bondy, Melissa Lynn, Du, Xianglin L., Hardy, Robert J., January 2007 (has links)
Thesis (Ph. D.)--University of Texas Health Science Center at Houston, School of Public Health, 2007. / "December 2007." Source: Dissertation Abstracts International, Volume: 68-11, Section: B, page: 7225. Advisers: Margaret R. Spitz; Ann Coker. Includes bibliographical references.

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