Spelling suggestions: "subject:"lungcancer"" "subject:"lungecancer""
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Lung Cancer in PeruRuiz, Rossana, Galvez-Nino, Marco, Poquioma, Ebert, Limache-García, Abel, Amorin, Edgar, Olivera, Mivael, Valdiviezo, Natalia, Trejo, Juan M., Heredia, Adela, Sarria, Gustavo, Aguilar, Alfredo, Raez, Luis, Neciosup, Silvia P., Gomez, Henry L., Payet, Eduardo, Mas, Luis 01 June 2020 (has links)
Peru is a South American nation with a growing and aging population of 31 million people with a life expectancy at birth of 76.7 years. The country is divided into 25 regions, 79% of the population is urban, and Lima, the capital, concentrates more than a third of the population.1 Although Peru is an upper-middle-income country, health expenditure represents only 5.1% of the gross domestic product, which is lower than the average of Latin America and the Caribbean (LATAM) (8.56%).2 Out-of-pocket health expenditure is 30.9%.3 Peru has a comprehensive National Cancer Plan and two population-based cancer registries in Lima and Arequipa. / Revisión por pares
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Kernel smoothing methodology for application in environmental epidemiologyKelsall, Julia E. January 1995 (has links)
No description available.
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Smoking and carcinoma of the lungLuke, William January 1954 (has links)
Thesis (M.D.)—Boston University
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The Role of Chronic Inflammation in the Development of Lung CancerBrenner, Darren 10 December 2012 (has links)
Inflammation is believed to play a pivotal role in the development of cancer and in particular
lung cancer through both intrinsic and extrinsic pathways. This thesis aimed through 4
manuscripts to determine the role of lung-specific inflammation-related exposures as well as
genetic variants (Single Nucleotide Polymorphism (SNPs)) in genes related to inflammation
pathways in lung cancer risk. Risk factors of particular interest were lung diseases including
emphysema, chronic bronchitis, pneumonia and tuberculosis. Data were collected from a
Toronto-based case-control study and combined with data from the International Lung Cancer
Consortium (17 studies for the non-genetic analyses and 6 studies for the genetic analyses). For
non-genetic data, methods included, but were not limited to, unconditional logistic regression
within single studies, Cox proportional hazards regression, meta-analytic techniques and pooled
analyses techniques. For genetic data, additive models of association across 7,650 SNPs
(selected based on role in inflammation) were pooled across studies and hierarchical modeling
iv
(HM) was used to incorporate prior functional information from various sources concerning the
SNPs of interest. Within the Toronto study (manuscript 1) associations with increased lung
cancer risk were observed for occupational exposures, previous lung diseases and a family
history of cancer. The meta-analysis (manuscript 2) and pooled analysis (manuscript 3) showed
relatively consistent associations between previous lung diseases and lung cancer risk across
histology, gender and smoking categories. Results persisted when examining lung disease
diagnoses made >10 or >20 years before cancer diagnosis. Our pathway-based analysis of
inflammation-related variants and lung cancer risk using HM (manuscript 4) showed that HM is
applicable to SNP analysis using pooled designs where heterogeneity can be incorporated into
SNP priors. After HM a previously observed variant (rs2736100) and novel variant (rs2741354)
were observed to be associated with lung cancer risk at corrected levels and replicated in an
independent population. Taken together these results provide further evidence of both intrinsic
and extrinsic factors affecting risk of lung cancer through inflammation.
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FER PROTEIN-TYROSINE KINASE AS A POTENTIAL THERAPEUTIC TARGET IN LUNG CANCERAhn, JOSEPH 08 September 2012 (has links)
Fer is a ubiquitously expressed non-receptor protein-tyrosine kinase that regulates normal physiology through signaling in a variety of cell types. Fer signals downstream of growth factor receptors frequently activated or amplified in human cancers and Fer has been identified as a positive regulator of cancer progression in the prostate and liver. Epidermal growth factor (EGF) receptor (EGFR) is frequently activated due to gene amplification or gain-of-function mutations in non-small cell lung carcinomas (NSCLC) leading to aggressive tumours that frequently metastasize. Since EGFR activates Fer, I tested whether Fer participates in EGFR-driven NSCLC cell migration, tumour progression and metastasis. Here, I show that Fer is expressed in cell lines derived from both normal lung epithelia and NSCLC and is activated following EGF treatment of NSCLC cells. To probe Fer function we used a lentiviral shRNA system to achieve stable knock-down (KD) of Fer in H1299 cells. Compared to control cells, Fer KD cells displayed a significant reduction in EGF-induced cell migration and invasion which correlated with reduced phosphorylation of the guanine nucleotide exchange factor Vav2. Consistent with Vav2 phosphorylation promoting Rac activation, we observed reduced localization of active, GTP- bound Rac1 to the leading edge of Fer KD cells treated with EGF. Tumour xenograft experiments were performed to test the role of Fer in NSCLC tumour progression and metastasis in immune compromised mice. Growth of primary tumours was normal, despite efficient Fer silencing in vivo. Interestingly, fewer spontaneous lung metastases were observed from subcutaneous Fer KD tumours compared to control. However, no differences were observed in lung seeding efficiency in experimental metastasis assays, suggesting that Fer may play a role in early stages of metastasis. Together, this study identifies Fer as a potential new therapeutic target for the treatment of EGFR-driven lung cancer metastasis. / Thesis (Master, Biochemistry) -- Queen's University, 2012-08-31 12:29:43.856
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Characteristics and interrelationships of cell lines derived from an undifferentiated bronchial carcinomaWright-Perkins, Shirley January 1992 (has links)
No description available.
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Endocrinology, oncogene expression and outcome in carcinoma of the lungRitchie, Andrew John January 1992 (has links)
No description available.
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The Role of Chronic Inflammation in the Development of Lung CancerBrenner, Darren 10 December 2012 (has links)
Inflammation is believed to play a pivotal role in the development of cancer and in particular
lung cancer through both intrinsic and extrinsic pathways. This thesis aimed through 4
manuscripts to determine the role of lung-specific inflammation-related exposures as well as
genetic variants (Single Nucleotide Polymorphism (SNPs)) in genes related to inflammation
pathways in lung cancer risk. Risk factors of particular interest were lung diseases including
emphysema, chronic bronchitis, pneumonia and tuberculosis. Data were collected from a
Toronto-based case-control study and combined with data from the International Lung Cancer
Consortium (17 studies for the non-genetic analyses and 6 studies for the genetic analyses). For
non-genetic data, methods included, but were not limited to, unconditional logistic regression
within single studies, Cox proportional hazards regression, meta-analytic techniques and pooled
analyses techniques. For genetic data, additive models of association across 7,650 SNPs
(selected based on role in inflammation) were pooled across studies and hierarchical modeling
iv
(HM) was used to incorporate prior functional information from various sources concerning the
SNPs of interest. Within the Toronto study (manuscript 1) associations with increased lung
cancer risk were observed for occupational exposures, previous lung diseases and a family
history of cancer. The meta-analysis (manuscript 2) and pooled analysis (manuscript 3) showed
relatively consistent associations between previous lung diseases and lung cancer risk across
histology, gender and smoking categories. Results persisted when examining lung disease
diagnoses made >10 or >20 years before cancer diagnosis. Our pathway-based analysis of
inflammation-related variants and lung cancer risk using HM (manuscript 4) showed that HM is
applicable to SNP analysis using pooled designs where heterogeneity can be incorporated into
SNP priors. After HM a previously observed variant (rs2736100) and novel variant (rs2741354)
were observed to be associated with lung cancer risk at corrected levels and replicated in an
independent population. Taken together these results provide further evidence of both intrinsic
and extrinsic factors affecting risk of lung cancer through inflammation.
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Predicting survival status of lung cancer patients using machine learningMohan, Aishwarya January 2021 (has links)
5-year survival rate of patients with metastasized non-small cell lung cancer
(NSCLC) who received chemotherapy was less than 5% (Kathryn C. Arbour,
2019). Our ability to provide survival status of a patient i.e. Alive or death at
any time in future is important from at least two standpoints: a) from clinical
standpoint it enables clinicians to provide optimal delivery of healthcare and b)
from personal standpoint by providing patient’s family with opportunities to
plan their life ahead and potentially cope with emotional aspect of loss of life. / Thesis / Master of Applied Science (MASc)
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Differential Effect of Selected Methylxanthine Derivatives on Radiosensitization and Cell Cycle in Normal and Lung Cancer Cell LinesMalki, Ahmed M. 06 October 2006 (has links)
No description available.
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