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Systemic lupus erythematosus in Hong KongWong, Kee-lam., 黃基林. January 1990 (has links)
published_or_final_version / Medicine / Master / Doctor of Medicine
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The genetic complexity and protein polymorphism of complement c4 in health and diseaseYang, Yan, January 2004 (has links)
Thesis (Ph. D.)--Ohio State University, 2004. / Title from first page of PDF file. Document formatted into pages; contains xviii, 212 p.; also includes graphics (some col.) Includes bibliographical references (p. 185-212). Available online via OhioLINK's ETD Center
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The role of interleukin-12 in the pathogenesis of human systemic lupus erythematosus /Liu, Tiefu. January 1998 (has links)
Thesis (Ph. D.)--University of Hong Kong, 1998. / Includes bibliographical references (leaves 137-161).
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Relationship adjustment, partner support, and psychosocial outcomes for women with systemic lupus erythematosus /Lewis, Traci Lyn. January 2002 (has links)
No description available.
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The role of interleukin-12 in the pathogenesis of human systemic lupuserythematosus劉鐵夫, Liu, Tiefu. January 1998 (has links)
published_or_final_version / Pathology / Doctoral / Doctor of Philosophy
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Gender, sex hormones and systemic lupus erythematosusMok, Chi-chiu., 莫志超. January 2002 (has links)
published_or_final_version / abstract / toc / Medicine / Master / Doctor of Medicine
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The role of peripheral dendritic cells in systemic lupuserythematosusJin, Ou, 金歐 January 2007 (has links)
published_or_final_version / abstract / Medicine / Doctoral / Doctor of Philosophy
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Association studies of systemic lupus erythematosus (SLE) : from novel susceptibility loci to gene-gene interactionZhang, Yan, 张彦 January 2012 (has links)
Systemic lupus erythematosus (SLE) is characterized as an autoimmune disorder with unclear etiology.
To identify the genetic effect of SLE, a genome wide association study (GWAS) and its further replication were conducted on SLE patients in Asian populations and ethnically matched controls. Before this study, most of the confirmed association loci were identified by GWAS studies in European populations. Apart from the established associations, we identified a SLE susceptible single nucleotide polymorphisms (SNP) located in ETS1 (rs1128334, P=2.3E-11, OR=1.29) in four different cohorts. This locus is probably an Asian-specific susceptibility locus since no Caucasian study has reported further validation in the last years. A new susceptibility variant in UHRF1BP1 (rs13205210, P=4.4E-09, OR=1.49) independent from the previously confirmed SNPs in Caucasian study was also confirmed to be associated with SLE in the Hong Kong Chinese population.
Meta-analysis was performed by introducing another Chinese Han GWAS data set from Anhui province, China. Three loci, TET3-DGUOK, CD80, DRAM1, were confirmed to be associated with SLE. Two loci with suggestive signals in Hong Kong GWAS and further replication were also confirmed by the meta-analysis: PTTG1-MiRNA146a, YDJC.
In order to identify the genetic effect for females who have predominant chance to suffer from SLE, X chromosome specific meta-analysis based on the Hong Kong and Anhui GWAS data and further replication study were performed by considering the difference between females and males. A signal in PRPS2, and three independent signals in the Xq28 were confirmed with the replication in three different cohorts by considering both females and males.
Gene-gene interactions were also investigated genome-widely in a hypothesis free manner based on the meta-analysis results. The further validation processes were preceeded based on each independent GWAS data set. Four pairswise interacting loci were found and cross validated by three methods including logistic regression and Multifactor Dimensionality Reduction (MDR) and information gain theory based on the Anhui GWAS data set. Further studies are still needed to better explain the real features of genetic epistasis and the potential biological roles.
By incorporating two GWAS from the same population, the population difference is efficiently avoided. Together with the putative gene-gene interactions, this study presents a comprehensive analysis based on the GWAS data conducted on SLE. It may shed new light on the disease mechanisms of SLE. / published_or_final_version / Paediatrics and Adolescent Medicine / Doctoral / Doctor of Philosophy
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Cognition dysfunction and disease and non-disease associated factors in systemic lupus erythematosus : longitudinal perspectivesGao, Yang, 高揚 January 2015 (has links)
abstract / Medicine / Doctoral / Doctor of Philosophy
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Antiphospholipid antibodies : a study of the nature and possible role in thrombosisKeeling, David Michael January 1996 (has links)
No description available.
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