Thesis (D.PT.)--Sage Colleges, 2010. / "May 2010." "A Capstone project for PTY 769 presented to the faculty of The Department of Physical Therapy Sage Graduate School in partial fulfillment of the requirements for the degree of Doctor of Physical Therapy." Includes bibliographical references.

Contexte La maladie de Lyme (ML), une zoonose transmise par une tique, est en émergence au Canada. Elle est à déclaration obligatoire au Québec depuis novembre 2003. Récemment, des cas ont été diagnostiqués chez des personnes n'ayant pas voyagé à l'extérieur de la province. La description complète des cas déclarés n'a pas été faite. L'objectif de cette étude est de décrire l'incidence, les manifestations cliniques et les facteurs de risque de la ML au Québec chez les cas signalés du 1er janvier 2004 au 31 décembre 2010. Méthode Une copie des dossiers de tous les cas signalés a été obtenue des DSP. Une grille standardisée a été utilisée pour la collecte des données. Les dossiers ont été classés selon la définition nosologique de 2010 (cas confirmé ou probable) à laquelle on a ajouté la catégorie "cas possible". Résultats Parmi les 108 cas signalés, 88 ont été retenus. Lors du reclassement, 40 dossiers ont changé de catégorie dont 23 cas considérés à l'origine comme non retenus. Parmi les 23 cas acquis au Québec, il y 3 cas confirmés, 11 probables et 9 possibles. Le nombre annuel de cas augmente progressivement, l'incidence passant de 0,01 à 0,28/100 000 entre 2004 et 2008. Les cas ont entre 2 et 86 ans (médiane de 43); 8 % ont moins de 10 ans et 58 % sont de sexe masculin. Un érythème migrant (EM), une arthrite ou une paralysie faciale ont été retrouvés chez 78 %, 20 % et 13 % des cas respectivement. L'EM est associé au sexe féminin (89 % vs 69 %, p=0,03). Les cas avec une paralysie faciale sont plus souvent hospitalisés (45 % vs 13 %, p<0,01). Seulement 34 % des cas ont été déclarés par un médecin, même si 98 % d'entre eux ont passé une sérologie pour la ML. Une activité en plein air, un séjour dans une zone endémique ou une piqûre de tique ont été rapportés par 87 %, 76 % et 31 % des cas respectivement. Discussion Le nombre de cas de ML augmente lentement au Québec. Le sud-ouest du Québec est à risque dû à la proximité géographique des zones endémiques. Les médecins n'ont déclaré qu'un tiers des cas et il y a une divergence entre la classification des DSP et celle de l'étude. Les caractéristiques cliniques des cas québécois sont similaires à celles observées aux États-Unis et en Allemagne, sauf pour la proportion de cas chez les enfants qui est plus faible qu'ailleurs.

Thesis (M. Phil.)--University of Hong Kong, 1996. / Includes bibliographical references (leaf 68-72).

No description available.

A total of 1,019 Amblyomma, americanum, 479 Dermacentor variabilis, 6 Ixodes texanus, and 1 I. dentatus ticks was collected from mammals and vegetation on three sites in Indiana, from March to October, 1986. Midgut diverticula were examined for the etiological agent, Borrelia burgdorferi, of Lyme disease (LD), using dark-field and immunofluorescence microscopy, and tissue samples cultured in BSK II medium for 7 to 21 days. Spirochetes were isolated in the BSK II medium from pools of midgut diverticula from 6 D. variabilis from Martin County and pools of midgut diverticula from 7 D. variabilis from Lawrence County. Spirochetes from Martin County differed morphologically from B. burgdorferi, and did not react positively to the rabbit anti-B. burgdorferi conjugate from the Montana NIH Laboratories. Spirochetes from Lawrence County were morphologically similar to B. burgdorferi, and reacted positively to direct immunofluorescence tests with rabbit anti-B. burgdorferi conjugate.Kidneys, spleens, and samples of blood were examined from 42 live-trapped white-footed mice (Peromyscus leucopus) for B. burgdorferi. No spirochetes were isolated from these organ cultures. Occasional human cases of Lyme disease in Indiana and the observation of spirochetes similar to B. burgdorferi in size and morphology from D. Variabilis ticks, suggest that B. burgdorferi may be present in Indiana. / Department of Biology

Thesis (Ph. D.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains x, 138 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 108-136).

published_or_final_version / Ecology and Biodiversity / Master / Master of Philosophy

No description available.

Bracken environments harbour the sheep tick (Ixodes ricinus), known vector of a number of diseases. Initial investigation indicated the presence of sheep ticks infected with the Lyme disease spirochaete Borrelia burgdorferi on open moorland areas of the North York Moors and the moorland areas of the South West of the U.K. Some aspects of the problem of Lyme disease on U.K. moorlands were explored in this study. A survey through the summer of 1993 of people using the North York Moors, Dartmoor and the Quantock Hills in Somerset for both work and leisure activities revealed a very high proportion of people (76% of respondents had not heard of Lyme disease) who were unaware of the risk of Lyme disease or of how they might reduce that risk. An examination of three moorland vegetation communities as optimal tick habitats suggested that immature ticks are less dense on heather dominated communities than on either bracken or on Vaccinium dominated communities, and that this may be influenced by the fauna using heather dominated areas. Vaccinium sites showed high densities of all life stages of the sheep tick, as did bracken dominated sites. Ticks were collected throughout the winter months on South Western sites, but not on the North York Moors, emphasising the year round risk from infected ticks in the South West of the U.K. Vegetation management practices as tick control or reduction options in these moorland areas were investigated. Asulam spraying on bracken almost totally removed the above ground frond cover, substantially reduced live buds on the rhizome, but failed to reduce the rhizome dry weight. The density of frond cover was not affected by cutting, height and dry frond weight were reduced, live rhizome buds reduced in number and rhizome dry weight reduced. Short term control of bracken fronds was achieved by both treatments, but neither treatment provided sufficiently conclusive results on which to base long term recommendations. Comprehensive plans for after care on treated sites need to be in place before treatment is carried out. Tick densities were recorded over a two year period on these treated bracken sites. There was a proportional reduction in all tick life stages between 1993 and 1994 on sites sprayed with asulam and on cut sites compared with control sites. Although not statistically significant these results suggested that the methods of bracken control investigated in this study could influence sheep tick densities in the short term.

The tick-borne Lyme disease, caused by the bacterium Borrelia burgdorferi, as well as some other Borrelia species, is the subject of a dispute as to whether its conditions persist following recommended antibiotic treatment lasting no more than three weeks. Advocates for the existence of chronic Lyme disease point to numerous animal models that show some traces of the bacteria remaining after treatment and call for both the long term use of antibiotics and for the disease to be recognized as chronic and to be diagnosed more expediently. Opponents of the existence of chronic Lyme disease argue that the scientific evidence for these arguments is insufficient, citing that long term symptoms are actually signs of other diseases erroneously grouped with Lyme, that current antibiotic regimens suffice for Lyme disease treatment, and that additional antibiotics beyond current treatments provide no increase in beneficial outcomes. The evidence currently is insufficient to support many of the claims by supporters of chronic Lyme disease and further studies must be done before evidence from the animal models can be applied to human patients. The fact that Borrelia burgdorferi in particular, and perhaps other members of the Borrelia genus, has evolved many singularly peculiar traits such as a lack of reliance on iron and a large extrachromosomal genome suggest that it is not outside the realm of possibility that there is some other facet of Lyme disease not currently recognized or understood. Future exploration is needed to fully understand mechanisms of pathogenesis of this bacterium in order to either confirm or deny the ability of Lyme disease to persist in humans following treatment.