Indigenous (Métis, First Nation, and Inuit) peoples and communities in Canada, especially in the prairies, continue to experience disproportionate levels of tuberculosis (TB) compared to the rest of the Canadian born population. This inequitable distribution of TB disease burden demands effective policy, program, and practice responses. These have so far failed to materialize, perhaps in part because of limitations in the approaches we have taken to understanding the issue. As well, these responses have largely been grounded in western scientific paradigms. Science is the search and the re-search for knowledge and this varies according to the perspectives and paradigms of the researcher(s) and stakeholders. In this project, the student researcher collaborated with the Métis Nation-Saskatchewan (MN-S) and two volunteer health researchers to adapt and ground a western paradigm and methodology (System Dynamics and Group Model Building) to a Métis research paradigm to understand experiences of tuberculosis (TB) among Métis people. Data collection took place in a 2-day Métis-adapted group model building (GMB) workshop. The outcome is a causal loop diagram with associated stories co-created by the team and the workshop participants. The workshop was evaluated using a storytelling and story listening method that explored the appropriateness of adapting GMB within a Métis research context. The approach was determined to be successful methodologically, and substantively new knowledge was created in our Métis community about the determinants of TB. This research was a journey of diversity, working at the intersection of knowledge systems to produce a new understanding of a health issue as complex as TB.