This study utilizes a hypercube innovation model to analyze the changes in both healthcare informatics and medical related delivery processes based on the innovations from Tele-health care, E-health care, to M-health care. Further, the critical impacts of the E-health innovations on the stakeholders: healthcare customers, hospitals, healthcare complementary providers, and healthcare regulators are identified. These results indicate that the innovation from Tele-health care to E-health care is architectural for healthcare customers, radical for both hospitals and healthcare complementary providers, and architectural for healthcare regulators. From E-health care to M-health care, innovation is architectural for both healthcare customers and hospitals, racial for healthcare complementary providers, and modular for healthcare regulators. Thereafter, the critical capabilities and suggestions for adopting each innovation are discussed