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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

M1 macrophages promote morphological changes and NF-KAPPA B nuclear translocation in prostate epithelial cells

Davis, Ahriea 01 July 2016 (has links)
In this study, we sought to define an underlying molecular mechanism of how inflammation induces cancer initiation. Cancer-associated inflammation is marked by the presence of inflammatory cells and mediators including cytokines, chemokines, and reactive oxygen species. There is a growing body of evidence establishing the link between chronic inflammation and cancer. Twenty percent of cancers have been linked to chronic infections. For instance, bacterial and viral infections induce inflammation which is a known risk factor for cancer. During inflammation, Ml macrophages' production of pro-inflammatory cytokines and reactive oxygen species (ROS) drives their function as anti-microbial. Likewise, the transcription factor nuclear factor kappa B (NF-KB) is known to induce a variety of stimulators, including ROS, to contribute to the inflammatory process. Therefore, we sought to explore the relationship between Ml macrophages and NF-KB, suggesting that Ml macrophage mediates cancer initiation via a NF-KB-dependent pathway, which collectively contributes to a metastatic phenotype.
2

The small GTPases Ras and Rap1 bind to and control TORC2 activity

Khanna, Ankita, Lotfi, Pouya, Chavan, Anita J., Montaño, Nieves M., Bolourani, Parvin, Weeks, Gerald, Shen, Zhouxin, Briggs, Steven P., Pots, Henderikus, Van Haastert, Peter J. M., Kortholt, Arjan, Charest, Pascale G. 13 May 2016 (has links)
Target of Rapamycin Complex 2 (TORC2) has conserved roles in regulating cytoskeleton dynamics and cell migration and has been linked to cancer metastasis. However, little is known about the mechanisms regulating TORC2 activity and function in any system. In Dictyostelium, TORC2 functions at the front of migrating cells downstream of the Ras protein RasC, controlling F-actin dynamics and cAMP production. Here, we report the identification of the small GTPase Rap1 as a conserved binding partner of the TORC2 component RIP3/SIN1, and that Rap1 positively regulates the RasC-mediated activation of TORC2 in Dictyostelium. Moreover, we show that active RasC binds to the catalytic domain of TOR, suggesting a mechanism of TORC2 activation that is similar to Rheb activation of TOR complex 1. Dual Ras/Rap1 regulation of TORC2 may allow for integration of Ras and Rap1 signaling pathways in directed cell migration.

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