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Differential proteome profiling analysis of murine skeletal muscle following a single bout of exerciseSmith, Laura Lindsay. January 2010 (has links)
Honors Project--Smith College, Northampton, Mass., 2010. / Includes bibliographical references (p. 121-131).
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Interleukin 20 receptor a (il20ra) is not the molecular basis of the mouse male sterility and histoincompatibility (mshi) mutation /Ye, Naiqing, January 2006 (has links)
Thesis (M.A.) -- Central Connecticut State University, 2006. / Thesis advisor: Thomas King. "... in partial fulfillment of the requirements for the degree of Master of Arts in Biomolecular Sciences." Includes bibliographical references (leaves 39-41). Also available via the World Wide Web.
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A threshold model for development of the corpus callosum in normal and acallosal mice /Bishop, Katherine Mary. January 1997 (has links) (PDF)
Thesis (Ph.D.)--University of Alberta, 1997. / Submitted to the Faculty of Graduate Studies and Research in partial fulfilment of the requirements for the degree of Doctor of Philosophy, Department of Psychology. Also available online.
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Use of Inbred Strains of Mice to Study the Genetics and Biology of Sperm FunctionByers, Shannon L. January 2006 (has links) (PDF)
No description available.
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Environmental and genetic factors determining growth and maturity in the mouseGarrard, Gwendoline January 1970 (has links)
No description available.
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Aspects of reproduction in the four-striped field mouse, Rhabdomys pumilioJackson, Claire January 2000 (has links)
Rhabdomys pumilio, in the Eastern Cape of South Africa, does not use short day length as an inhibitory cue for reproductive activity, and, despite previous records indicating that these mice are strictly seasonal in their reproduction, litters have been found during the winters of some years,both in the Eastern Cape and in the Western Cape. This led me to believe that the reproductive activity of Rhabdomys pumilio is more opportunistic and that the cue or cues used to control reproduction are less predictable and, or more variable than the photoperiod cue used by many seasonally reproducing rodents. Two experiments were conducted, investigating the influence of low ambient temperature (15⁰C)and reduced food availability on the reproductive activity of both male and female four striped field mice. Mice were maintained in one of four conditions (food restricted at 15⁰C, food restricted at 26⁰C, ad lib. food at 15⁰C, and ad lib. food at 26⁰C) for 4 (males) and 8 weeks (females)(photoperiod 12L:12D, humidity 40%). Results indicated that the males reduced their reproductive activity slightly when exposed to either low temperature or low food availability and that maximum inhibition of reproduction occurred when mice were exposed to both low temperature and low food availability. However, female reproductive activity was inhibited when exposed to low food availability, irrespective of the temperature. Both sexes of mice showed varying abilities to resist fat loss and, in the males, the size of the fat store had a significant effect on reproduction. This varying ability to resist fat loss could be related to levels of activity and in the females (where activity was quantified), high activity scores were significantly associated with reproductive inhibition. These results support the hypothesis that reproduction in Rhabdomys pumilio is opportunistic and controlled by the availability of energy. I propose that the females will be more sensitive to reproductive inhibition due to their far greater post-fertilization responsibilities, where the reproductive activity of the females is rapidly inhibited by a reduction in food availability, while the males are less readily inhibited by low food availability or low temperature, unless the change in the controlling factors is severe enough, or prolonged, at which stage their reproductive activity will cease. The significance of opportunistic reproduction in the seasonal but unpredictable climate of the study area is discussed.
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The causes and consequences of stereotypic behaviour in the striped mouse, rhabdomysJones, Megan Anne 27 August 2012 (has links)
ABSTRACT
Environmentally-induced stereotypic behaviour (SB) results from the chronic impact of
captivity on brain development and function and, consequently, on behaviour. My study
sought to determine group- and individual-level predictors and correlates of SB in the striped
mouse, Rhabdomys dilectus, and to identify the mechanisms underlying the stereotypic
phenotype. This aim was addressed by collecting cross-sectional and longitudinal behavioural
and physiological data from a combination of wild-caught (WC) and captive-born (CB)
striped mice born and reared in different social and environmental conditions. First, I
examined the group-level effects of rearing conditions. Results confirmed the genetic
contribution to SB performance in striped mice, and furthermore indicated that (1) striped
mice weaned at or later than their natural weaning age are less likely to develop SB than
striped mice weaned prematurely; (2) striped mice reared biparentally showed significantly
less SB as adults than striped mice reared by their mothers alone; (3) striped mice raised from
weaning in enriched conditions were four times less likely than standard-housed individuals
to develop SB, an effect which endured after enriched-housed striped mice were transferred
to standard housing; and (4) birth origin predicts the emergence of SB in striped mice, with
those WC individuals trapped as adults being relatively protected from the development of
SB compared with both WC individuals trapped as juveniles and CB striped mice. I also
showed that (1) WC striped mice were more fearful and less active than CB animals, but that
these traits did not covary with SB, and (2) WC striped mice were less perseverative and
behaviourally more flexible than CB animals, traits that did covary with SB. Second, I
characterized the developmental trajectory of SB in a large group of CB, standard-housed
striped mice, and then investigated potential individual-level predictors, mediators, and
correlates of SB in these animals. Measures of perseveration, activity, and anxiety/fearfulness
assessed in juveniles before the development of SB did not predict which animals later
developed SB, but stereotypic adults were more active and more perseverative than nonstereotypic
individuals. Whilst preweaning developmental maturity did not predict which
striped mice later developed SB, striped mice showing accelerated development in the
preweaning period were likely to show SB at an earlier age, at a higher frequency, and
potentially with reduced variability, effects which persisted into adulthood. In conclusion, my
study shows that more naturalistic rearing environments reduce the incidence of SB, an effect
mediated by genetic factors and possibly also by experience-dependent alterations in
forebrain function. However, further work is necessary to explore whether the association
between forebrain function and SB expression in striped mice is causal because, whilst
environments which decrease perseverative tendencies also reduce SB, I found no evidence
that such tendencies predict which striped mice later develop SB.
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Molecular genetics of Rhabdomys subspecies boundaries : phylogeography of mitochondrial lineages and chromosomal fluorescence in situ hybridizationRambau, Ramugondo Victor 03 1900 (has links)
Thesis (PhD)--University of Stellenbosch, 2003. / ENGLISH ABSTRACT: The geographic genetic population structure and evolutionary history of the African
four-striped mouse, Rhabdomys pumilio, was investigated using mitochondrial
(mtDNA) cytochrome b gene (1140 bp) and control region (994 bp) sequences and a
combination of cytogenetic banding techniques (G- and C-banding), and
fluorescence in situ hybridization. Two cytotypes (2n = 46 and 2n = 48) were
identified by cytogenetic analysis. No evidence of diploid number variation within
populations was found nor were there differences in gross chromosome morphology,
or subtle interchromosomal rearrangements at levels detected by ZOO-FISH. The
comparative painting data (using the complete suite, N = 20, of Mus musculus
chromosome specific painting probes) show that 10 mouse chromosomes have been
retained as chromosomal arms, or intact chromosome blocks within the R. pumilio
genome, six produced double signals, while the remaining four hybridized to three or
more R. pumilio chromosomes. In total, the 20 mouse chromosome paints detected
40 segments of conserved synteny. Their analysis revealed eight R. pumilio specific
contiguous segment associations, a further two that were shared by R. pumilio and
other rodents for which comparable data are available, the Black (Rattus rattus) and
Norwegian (Rattus nONegicus) rats, but not by the Chinese hamster, Cricetulus
grise us. The results suggest that mouse chromosomes 1, 10, and 17 have
undergone extensive rearrangements during genome evolution in the murids and
may be useful markers for enhancing our understanding of the mode and tempo of
chromosome evolution in rodents. Following initial studies using control region
sequences, the phylogeographic appraisal of R. pumilio was done using cytochrome
b gene sequences. Analyses based on a variety of analytical procedures resulted in
the detection of two major mtDNA lineages that correspond roughly to the xeric and
mesic biotic zones of southern Africa. One clade comprises specimens with 2n = 48,
and the other representatives of two cytotypes (2n = 48 and 2n = 46). The mean
sequence divergence (12.0%, range 8.3% -15.6%) separating the two mtDNA clades
is comparable to among-species variation within murid genera suggesting their
recognition as distinct species, the prior names for which would be R. dilecfus and R.
pumilio. Low sequence divergences and the diploid number dichotomy within the
mesic lineage support the recognition of two subspecies corresponding to R. d.
dilecfus (2n = 46) and R. d. chakae (2n = 48). The data do not support subspecific
division within the nominate, R. pumilio. Molecular dating places cladogenesis of the
two putative species at less than 5 million years, a period characterised by extensive
climatic oscillations which are thought to have resulted in habitat fragmentation
throughout much of the species' range. / AFRIKAANSE OPSOMMING: Die geografiesebevolkingsstruktuur en evolusionêre verwantskappe binne die Afrika
streepmuis, Rhabdoys pumilio, is ondersoek deur middel van mitochondriale ONS
volgordebepaling van die geenfragment sitochroom b (1140 basispare) en die
reguleerstreek (994 bp) in kombinasie met sitogenetiese tegnieke (G- en Cbandkleuring
en f1uoreseerende in situ hibridisasie). Twee sitotipes (2n = 46 en 2n =
48) is geidentifiseer deur sitogenetiese analasie. Geen bewys van variasie in die 2n
chromosoomgetal binne bevolkings is gevind nie. Verder is daar ook geen verskil in
die morfologies struktuur van chromosome aanwesig binne bevolkings nie.
Vergelykende data (verkry met behulp van die N = 20 Mus musculus
chromosoomspesifiekepeilers) dui daarop dat 10 muis chromosome behoud gebly
het as chromosoomarms of chromosoomblokke binne die R. pumilio genoom. Ses
peilers het dubbel seine gelewer terwyl die oorblywende vier peilers gehibridiseer het
aan drie of meer R. pumilio chromosome. In totaal het die 20
muischromosoomverwe 40 konserwatiewe segmente geidentifiseer. Die analise dui
agt R. pumilio spesifieke aaneenlopende segmentassosiasies aan, met 'n
addisionele twee wat deur R. pumilio en ander muisagtiges vir wie vergelykende data
beskikbaar is, byvoorbeeld die swart (Rattus rattus) en Noorweegse (R. norvegicus)
rot maar nie die Chinese hamster, Cricetulus grise us, gedeel word. Die resultate stel
voor dat muischromosoom 1, 10 en 17 ekstensiewe herrangskikkings ondergaan het
gedurende die genoom evolusie binne die Muridae en dat hulle waarskynlik
waardevolle merkers kan wees om beide die patroon en tempo van chromosome
evolusie in muisagtiges verder te kan verstaan. Die filogeografiese verwantskappe
binne R. pumilio is ondersoek deur middel van ONS volgordebepalings van die
reguleerstreek asook sitochroom b. Die resultate van hierdie studie het twee
divergente mitochondriale ONS eenhede ontdek wat gekorreleer kan word met
xeriese en mesiese klimaatsones binne suidelike Afrika. Een groep bestaan uit diere
met 2n = 48, terwyl die ander genetiese groep twee sitotipes (2n = 46 en 2n= 48)
insluit. 'n Gemiddelde genetiese divergensie van 12.0% (varieer tussen 8.3% -
15.5%) verdeel die twee mtDNS-groepe en is vergelykbaar met tussenspesievariasie
binne ander muisagtige genera, wat moontlik daarop dui dat twee verskillende
spesies teenwoordig is; die voorgestelde name is R. di/ectus en R. pumilio. Lae
genetiese divergensie binne die mesiese groep versterk die moontlike
teenwoordigheid van twee subspesies, R. d. di/ectus (2n = 46) en R. d. chakae (2n =
48). Die data verleen egter nie steun aan die divisie binne R. pumilio nie.
Molekulêre datering van die twee spesies dui daarop dat die divergensie ten minste 5
miljoen jaar gelede plaasgevind het. Die periode was gekarakteriseer deur ekstensiewe klimaatsossilasies, wat gely het tot habitat fragmentasie in die spesie se
verspreidingsgebied.
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Prenatal exposure to low doses of estrogen reproductive effects in male and female mice and implications for regulation of endocrine disrupting environmental chemicals /Thayer, Kristina A. January 1999 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 1999. / Typescript. Vita. Includes bibliographical references (leaves 92-107). Also available on the Internet.
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Identification, expression and characterization of Murine pepsinogen F /Chen, Xiaodi, January 2000 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2000. / Typescript. Vita. Includes bibliographical references (leaves 189-242). Also available on the Internet.
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