Thesis advisor: Jeremy D. Shakun / Arctic permafrost contains a substantial stock of carbon that could be released to the atmosphere as CH4 and CO2 upon thawing, making it a potentially powerful amplifier of future warming. The sensitivity of permafrost to climate change is uncertain, however, and occurs on time scales longer than those captured by the instrumental record. Speleothems – cave precipitates deposited from flowing or dripping water – in currently frozen regions record past episodes of thaw, which can be used to assess the response of permafrost to long-term warmth. Here, we present 90 uranium-thorium ages on speleothems from across the North American Arctic, sub-Arctic and northern alpine regions to reconstruct a 600-kyr permafrost history. Widespread speleothem growth supports an episode of extensive permafrost thaw during the Marine Isotope Stage 11 interglacial about 400 ka, when global temperature was only slightly warmer than pre-industrial conditions. Additional growth is evident during MIS 13, curiously, a smaller magnitude interglacial. Ice-core records of atmospheric greenhouse gases do not show elevated concentrations at these times, perhaps suggesting that the permafrost carbon pool was smaller than today or released gradually enough to be buffered by other reservoirs. / Thesis (MS) — Boston College, 2017. / Submitted to: Boston College. Graduate School of Arts and Sciences. / Discipline: Earth and Environmental Sciences.