NDLTD Global ETD Search
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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.

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Spelling suggestions: "subject:"MPTP (1dimethyldiphenylmethyl"" "subject:"MPTP (1methyldiphenylmethyl""

1

Dopamine Receptor Plasticity Following MPTP-Induced Nigrostriatal Lesions in the Mouse

Weihmuller, Frederic B., Bruno, John P., Neff, Norton H., Hadjiconstantinou, Maria 16 May 1990 (has links)
MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) destroys dopamine-containing nigrostriatal neurons and increases the apparent Bmax of both D1 and D2 binding sites in the striatum. However, the changes of Bmax occur at different intervals after the lesion. Up-regulation of D2 sites becomes evident about 3 weeks after the lesion and lasts for about 3 months. In contrast, about 3 months are required for the up-regulation of D1 sites and increased binding is still evident after 5 months.
Dopamine D receptors 1
Dopamine D receptors 2
MPTP (1-methyl-4-phenyl-1
2
3
6-tetrahydropyridine)
receptor up-regulation
striatum

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