AIM:  to evaluate the flow, working time, setting time, film thickness and solubility of a novel root canal sealers (MTA Fillapex) in comparison with a zinc oxide-eugenol– based sealer (Tubli-Seal), epoxy resin-based sealers (AH 26), a calcium hydroxide-based sealer (Apexit Plus), and a silicone-based sealer (ReokkoSeal Automix). MATERIALS AND METHODS: ISO 6876/20012 specifications were followed except for the solubility test. Solubility was measured by the amount of material extracted from the specimens left in water over 24 hr period. Film thickness was measured as the distance between weighted glass slides containing a standard quantity of sealer. Flow was assessed by rate of sealer extrusion through a standard bore diameter, after unit time. Working time was taken as the point at which flow rate was reduced by 10%. The indentation test using a modified Gilmore needle was employed to investigate the setting times. RESULTS: ReokkoSeal Automix and MTA Fillapex were the least soluble, whilst Tubli- Seal was the most unstable in water. Also, Tubli-Seal had the highest film thickness. All sealers showed comparable flow rates. The working time varied from 30 min for MTA Fillapex to 4 hr for AH 26. The range of setting times recorded was from 64 min for Tubli-Seal Xpress to more than 5 hr for AH 26. CONCLUSIONS: MTA Fillapex and RoekoSeal Automix showed the greatest stability in Solution. The film thickness values in increasing order were: AH26 < Apexit plus = RoekoSeal Automix < MTA Fillapex < Tubli-Seal Xpress. The flow rates for Tubli-Seal xpress, AH26, and RoekoSeal Automix are statistically similar, while Apexit plus and MTA Fillapex are statistically similar. The working times for all sealers were greater than 30 min. AH26 did not set when incubated in volumes sufficient to fill the test matrices. / 2018-09-28T00:00:00Z