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Microtubule Dynamics, Kinetochore Number, and Kinetochore Distribution in Cells Undergoing Mitosis with Unreplicated GenomesClark-Cotton, Manuella Rossette 17 May 2014 (has links)
In cells undergoing mitosis with unreplicated genomes (MUG), anaphase is successfully initiated despite the abundance of kinetochores that are attached to microtubules emanating from both spindle poles (merotely). In cultured cells, merotely is associated with lagging at the metaphase plate. Treatment with microtubule-perturbing drugs alters the frequency of lagging, but the effect of these drugs on MUG cells is unclear. In this study, low doses of a microtubule-stabilizing drug, taxol, or a microtubule-destabilizing drug, nocodazole, dramatically increased the frequency of lagging kinetochores in the midbody of MUG daughter cell pairs. Likewise, increasing the kinetochore number increased the frequency of lagging kinetochores. In this thesis, these data are used to propose a model of mitosis in which the bipolar attachments of MUG cells are reduced to monopolar attachments that are stabilized by their perpendicular orientation with respect to the kinetochore, allowing for spindle assembly checkpoint satisfaction without centromeric tension.
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Rogue GalleryArnett, Joanne M. 24 April 2013 (has links)
No description available.
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Accumulation of Divine ServiceAtwood, Blaine Lee 01 March 2014 (has links) (PDF)
Accumulation of Divine Service is a ceramic installation referencing the sublime attribute of service, and how it relates to our temporal existence. Many aspects of the sublime are implemented into the contemporary art world today. The sublime can refer to ideas from terror to joy, and all across the spectrum of human emotions. The unifying element that seems to tie them together is a quality of awe-inspiring greatness, or the metaphysically divine. These attributescan inspire the mind and often lead one to dwell on the existence of a Supreme Being or Deity,what His purposes are, and how we as mortals work with or for that purpose.This installation encompasses some of my thoughts on the divinity that I believe dwells within all mankind. I do this by incorporating into the installation two repeated elements, the finial and the mug. The finial is an architectural element that is implemented at the apex of most religious meetinghouses. It is used for this purpose because it points toward the heavens and lifts the mind upward toward God. The mug, on the other hand, is one of the most humble and universal ceramic service vessels. It is used around the world as a drinking container whose sole purpose is service, or to give life-sustaining nourishment to mankind. The combination of these two visual elements seeks to encompass my personal art practice, my research, and the element of the sublime that we all possess.
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Expression Profiling and Recombinant Production of TomEP, a Tomato Extensin PeroxidaseMishler-Elmore, John William 02 June 2020 (has links)
No description available.
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