Mesenchymal stem cells (MSCs) are the most widely used source for bone tissue engineering due to their capability of multipotent differentiation. The use of nanotechnology in biomedical applications and therapy has increased in recent years provides an elegant alternative in comparison to current tissue engineering methods. Magnetic nanowires have a high potential in the medical field, as they are biocompatible, are simple to fabricate, possess low cytotoxic effects and can be operated wirelessly via magnetic fields. A nanowire substrate (NW) can provide a surface with tunable elastic properties. Therefore, magnetic nanowires have many promising applications such as in cell therapy, cell separation, cancer treatment, and as a scaffold for cell culture. This thesis explores the effects of alternating magnetic field (AMF) as a biophysical stimulator of osteogenic differentiation of MSCs by culturing the stem cells on a magnetic iron (Fe) NW. To this end, Fe nanowires were fabricated through electrodeposition and interactions between the NW and cells were analysed by electron microscopy. An AMF was applied to the NW in order to induce a vibration. MSCs were exposed to different magnetic field intensities, 250 mT and 50 mT, for different application times, 12 hours on followed by 12 hours off for two days and 24 hours on followed by 12 hours off. Differentiation was determined through the assessment of osteogenic markers at the mRNA level by RT-PCR and at the protein level by flow cytometry and fluorescence microscopy. Different effects were observed on MSCs grown on Fe NWs following exposure to different magnetic field intensities and duration applications. MSC differentiation towards the osteogenic lineage increased with increased field intensities. The most enhanced osteogenic differentiation of MSCs was observed at 250 mT AMF for 12 hours, as evidenced by elevated osteogenic markers at mRNA level compared to that of an AMF free control. Based on these results, we proposed that culturing MSCs on magnetic nanomaterials has the potential to control and promote osteogenesis under magnetic field and without the addition of external differentiation factors. These findings provide a new tool for stem cell research as an effective technology for bone tissue engineering and regenerative medicine.

Terrestrial iron oxides, such as hematite, goethite and magnetite, form specifically cemented concretions in sandstones using an aqueous diagenetic solution. According to the new results, the timeline on which concretions are formed could be much larger than current estimates. The basis for this claim is a magnetic record of the Jurassic Navajo Sandstone in Utah. The record contains fluctuations of remanent magnetization, which could prove the inversion of the Earth's magnetic field. This observation suggests that the time axis of the accumulation of iron concretions is comparable to the time axis of the accumulation of marine iron-manganese nodules, which contain a complex magnetic record. The occurrence of extremely slow changes in iron deposition in sandstones also helps to better understand the origin of concretions. In addition, terrestrial concretions provide an analogy for the "blueberries" found by the Mars rover Opportunity on Mars. These concretions probably underwent similar formation processes and could record inversions of the early magnetic dynamo on Mars.

京都大学 / 0048 / 新制・課程博士 / 博士(理学) / 甲第19359号 / 理博第4121号 / 新制||理||1593(附属図書館) / 32373 / 新制||理||1593 / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)教授 一本 潔, 教授 柴田 一成, 准教授 野上 大作 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

Electro-dynamic suspension (EDS) Magnetic levitation (Maglev) with its advantage in maintenance, safety, efficiency, speed, and noise is regarded as a leading candidate for the next generation transportation / space launch assist system. The Halbach array due to its unique magnetic field feature has been widely used in various applications. The EDS system using Halbach arrays leads to the potential EDS system without super-conductor (SC) technology. In this thesis, the Halbach array magnetic field and the dynamics of a novel Halbach array EDS Maglev system were considered. The practical Halbach array magnetic field was analyzed using both a Fourier series approach and the finite element method (FEM). In addition, the optimal Halbach array geometry was derived and analyzed. A novel active magnetic array was introduced and used in the Halbach array EDS Maglev configuration. Further more, since the system is self-regulated in lateral, roll, pitch, and yaw directions, the control was simplified and can be implemented electronically. The dynamic stability analysis and simulation results showed that the system is marginally stable and a control mechanism is needed for stability and ride comfort control. The six degree of freedom (DOF) dynamics, and the vehicle's mass center offset effects on those dynamics were investigated with multiple passive and active magnetic forces. The results indicated that the vehicle's mass center offset has a strong effect on the dynamics of the Maglev system due to the uniqueness of the magnetic force and also that the mass center offset can cause Maglev oscillations at the take off stage. In order to guarantee the dynamic stability and ride comfort of the Maglev system, an optimized active damping and a linear quadratic regulator (LQR) control were developed. Finally, the simulation confirmed the effectiveness of the proposed multi-input and multi-output (MIMO) control designs.

yes / We derive two principal components (PCs) of temporal magnetic field variations over the solar cycles 21–24 from full disk magnetograms covering about 39% of data variance, with σ = 0.67. These PCs are attributed to two main magnetic waves travelling from the opposite hemispheres with close frequencies and increasing phase shift. Using symbolic regeression analysis we also derive mathematical formulae for these waves and calculate their summary curve which we show is linked to solar activity index. Extrapolation of the PCs backward for 800 years reveals the two 350-year grand cycles superimposed on 22 year-cycles with the features showing a remarkable resemblance to sunspot activity reported in the past including the Maunder and Dalton minimum. The summary curve calculated for the next millennium predicts further three grand cycles with the closest grand minimum occurring in the forthcoming cycles 26–27 with the two magnetic field waves separating into the opposite hemispheres leading to strongly reduced solar activity. These grand cycle variations are probed by α − Ω dynamo model with meridional circulation. Dynamo waves are found generated with close frequencies whose interaction leads to beating effects responsible for the grand cycles (350–400 years) superimposed on a standard 22 year cycle. This approach opens a new era in investigation and confident prediction of solar activity on a millenium timescale.

<p> A high-resolution, low-noise far-infrared Fourier transform spectrometer system has been developed and utilized to study optical absorption in the III-V compound semiconductor InSb.</p> <p> Its electron effective mass was investigated, using cyclotron resonance absorption, as a function of magnetic field and compared with a theory originated by Kane (1957). The agreement was good and accurate values of the band edge effective mass and effective g factors were determined. Resonant electron-LO phonon coupling between the n = 2 and n = 0 + wLO Landau levels was observed and the polaron effective mass enhancement measured as a function of magnetic field. Comparison with Larsen's theory (1966), permitted an accurate value of the coupling constant to be derived. The temperature dependence of the electron effective mass was shown to be primarily due to dilation of the crystal lattice in confirmation of other workers' suggestions. However, some discrepancy, whose origin is unknown, was found to exist between experiment and theory.</p> <p> Single phonon absorption by the longitudinal optic phonon mode at the zone center was observed on the side of the main Reststrahl band in a thin sample. The shapes, frequencies and intensities of far-infrared absorptions attributable to two-phonon processes were found to compare favourably with a theoretical two-phonon density of states curve calculated by G. Dolling (1972). The parameters used in the theory were derived from inelastic neutron scattering experiments. Two phonon combinations and their locations in the Brillouin zone which give rise to strong features in the two-phonon density of states were identified by comparing theory and experiment. Important critical points were discovered to be located on or near the zone boundary and not only at the symmetry points X and L as previously suggested. The frequency shifts of some two-phonon features were measured as a function of temperature and analyzed in terms of a quasi-harmonic lattice dilation component and an anharmonic component. The two terms were found to be mirror images as a function of temperature.</p> / Thesis / Doctor of Philosophy (PhD)

<p> A detailed theoretical analysis of the propagation constant and the field components in rectangular waveguide completely filled with a semiconductor subjected to an external transverse applied magnetic field, has been carried out. A numerical solution of the transcendental equation for the propagation constant has been obtained for the n-type germanium samples with different conductivities and magnetic fields. </p> <p> An experimental verification of this theoretical analysis has been made with a 22.2 ohm-em, n-type germanium sample at 9.46 GHz. The applied transverse magnetic field was varied from 0 to 10 Kilogauss. Measurements of the reflection co efficients at the air-semiconductor interface for different values of the applied magnetic field have been made with a high precision microwave reflection bridge. The experimental results agree well with the theoretical results. </p> / Thesis / Master of Engineering (MEngr)

This investigation is an attempt to verify the original work done by George Antonoff and Anne Rowley, and to contribute specific data on the action of a magnetic field on aluminum cells. Experiments of the type they have described have been performed and an extensive set of data has been collected. It was thought that if the results of Antonoff and Rowley could be duplicated, further investigation would be warranted. However, the experiments have produced negative results. These results are described in detail in these chapters.

京都大学 / 新制・課程博士 / 博士(理学) / 甲第24421号 / 理博第4920号 / 新制||理||1703(附属図書館) / 京都大学大学院理学研究科物理学・宇宙物理学専攻 / (主査)教授 一本 潔, 准教授 浅井 歩, 教授 横山 央明 / 学位規則第4条第1項該当 / Doctor of Science / Kyoto University / DFAM

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