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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Development of Novel Physical Methods to Enhance Contrast and Sensitivity in Magnetic Resonance Imaging

Jenista, Elizabeth January 2010 (has links)
<p>The purpose of this thesis is to report technological developments in contrast mechanisms for MRI. The search for new forms of contrast is on-going, with the hope that new contrast mechanisms and new contrast agents will provide unique insights into various molecular processes and disease states. In this thesis, we will describe new contrast mechanisms developed by manipulating the inherent physics of the system, as well as the development of exogenous contrast agents. More specifically, we will describe the application of iMQCs (intermolecular multiple quantum coherences) to thermometry and structural imaging, and the unique information provided from these studies. We will also describe methods for migrating iMQC-based pulse sequences from a Bruker research console onto a clinical GE console, thus enabling the application of iMQCs to humans. We will describe the development of hyperpolarized contrast agents which have the potential to provide an unprecedented level of molecular contrast to MRI and the development of techniques to enhance the lifetime of these hyperpolarized contrast agents. Finally, we will discuss a new type of T2 -weighted imaging which significantly improves the refocusing of CPMG-type sequences.</p> / Dissertation
2

Role of magnetic resonance and wave interference in tailoring the radiative properties of micro/nanostructures

Wang, Liping 11 November 2011 (has links)
The spectral and directional control of radiative properties by utilizing engineered micro/nanostructures has enormous applications in photonics, microelectronics, and energy conversion systems. The present dissertation aims at: (1) design and analysis of micro/nanostructures based on wave interference and magnetic resonance effects to achieve tunable coherent thermal emission or enhanced optical transmission; (2) microfabrication of the designed structures; and (3) development of a high-temperature emissometer to experimental demonstrate coherent thermal emission from fabricated samples at temperatures from 300 K to 800 K. Asymmetric Fabry-Perot resonant cavities were studied as a potential coherent emission source. The reflectance was measured at room temperature using a Fourier-transform infrared spectrometer, and the emittance can be indirectly obtained from Kirchhoff's law. A high-temperature emissometer was built to measure the thermal emission of fabricated samples, and the temperature effect on the emission peaks was discussed. The direct and indirect approaches were unified and a generalized Kirchhoff's law was deduced to calculate thermal emission from layered structures with nonuniform temperatures. Magnetic polaritons were identified as a mechanism for achieving extraordinary optical transmission/absorption, through the comparison between equivalent capacitor-inductor models and the rigorous coupled-wave analysis. With carefully tuned geometric parameters, the resonance frequencies can be tailored for specific applications. A coherent emission source was designed with grating structures by excitation of magnetic polaritons, and is well suitable for thermophotovoltaic applications, thanks to the spectral selectivity and directional insensitivity of magnetic polaritons. Test samples were fabricated, and coherent thermal emission was experimentally observed at room temperatures up to 800 K. The results obtained in this dissertation will facilitate the design and application of micro/nanostructures in energy-harvesting systems.

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