Approved for public release; distribution is unlimited. / The USS Winston S. Churchill (DDG-81) shock trial was conducted in May and June of 2001 off the coast of Naval Station Mayport, Florida. Because the USS Winston S. Churchill best represented the new line of Flight II-A Arleigh Burkes, it was chosen to undergo ship shock trials for its class. These trials are necessary in order to evaluate the vulnerability and survivability of the hull and the mission essential equipment in a "combat shock environment". However, shock trials are very expensive, require extensive planning and coordination, and represent a potential hazard to the marine environment and its mammals. Computer modeling and simulation are showing themselves to be a plausible alternative in investigating the dynamic response of a ship under these shock trials conditions. This thesis investigates the use of computer ship and fluid modeling, coupled with underwater explosion simulation and compares it to actual shock trial data from the USS Winston S. Churchill. Of particular concern in this study is the amount of fluid that must be modeled to accurately capture the structural response of a full ship finite element model. Four fluid meshes were constructed and used to study the ship's response to an underwater explosion. Each simulation data was analyzed to determine which mesh best represented the actual ship shock trial results. / Lieutenant, United States Navy

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acase@tulane.edu / Influenza is a highly contagious viral respiratory infection that occurs in annual outbreaks. Activity levels for the 2017-2018 influenza season reached heights not seen since the 2009 pandemic. This was partly due to the inefficiency of the vaccine (25% effective) against the predominant circulating strain, H3N2. To make matters worse, current antiviral therapies must be given within 48 hours of the onset of symptoms. This is often well outside the window of opportunity for hospitalized patients. Developing a therapy that promotes repair of the extensive damage that occurs in severely infected patients is vital for their recovery. Our lab focuses on the innate immune response, more specifically the IL-22 pathway, and the mechanisms involved in repair following pulmonary injury and infection. IL-22 is important in cell proliferation, wound healing, maintaining epithelial barriers and innate pathogen defense. In the lung, its receptor, IL-22Ra1, is only found on epithelial cells and is rapidly induced in response to damage of the lung epithelium. The central hypothesis of this dissertation is that IL-22Ra1 is induced during influenza infection on pulmonary epithelial and progenitor cells, allowing for enhanced sensitivity to IL-22. We have found this induction to be TLR3 and STAT1 dependent. In vivo, bronchial brushings from H1N1 infected mice (PR/8/34) mice demonstrate that Il-22ra1 is rapidly induced in the airways following infection. This occurs in a STAT1 dependent manner as upregulation does not occur in STAT1-/- mice in vivo or following STAT1 inhibition in vitro. This pathway is important as IL-22 treatment induces expression of tight junction transcripts both in vitro and in vivo. Moreover, we believe this induction of IL-22Ra1 is critical for the survival of lung progenitor cells as we have data showing that over 80% of basal cells express Il-22ra1 in the naïve lung. Furthermore, we have developed a lung organoid model and upon treatment with IL-22, organoid size was significantly increased after seven days as evidenced by measurement and BrdU incorporation. Overall, our data shows that IL-22Ra1 is highly induced after injury and subsequent treatment with IL-22 is essential for altering tight junctions and promoting lung repair. / 1 / Kelly Douglas Hebert II

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This research explores the application of expert systems to the maintenance of boilers, are as follows: and its main objectives [1] To explore the application of expert systems in the maintenance of boilers. [2] To simplify the task of boiler maintenance with the help of expert systems. [3] To improve the skills of boiler maintenance workers through the knowledge 'captured ' or 'preserved' by expert systems. [4] To minimise errors which may cost time, money, effort and possible risk of injury to boiler maintenance personnel. [5] To develop a prototype expert system which can advise and assist boiler maintenance personnel. [6) To contribute to research in the application of expert systems in the field of engineering.

Thesis (M.S.)--Massachusetts Institute of Technology, Dept. of Civil Engineering, 1980. / MICROFICHE COPY AVAILABLE IN ARCHIVES AND ENGINEERING. / Bibliography: leaves 151-153. / by Paul J. Haven. / M.S.

M. Tech. Civil Engineering.. / Investigates the feasibility of recycling construction waste for re-use as raw material in rehabilitation of roads in Bethal (Govan Mbeki Municipality). Specific Objectives: (a) To identify the causes of roads failure within the study area.(b) To assess feasibility of reuse of construction waste and propose method of road rehabilitation.(c) To recycle unsuitable material through characterisation of the construction waste. (d) To compare the cost implications when recycled construction waste is used with that of normal roads' rehabilitation.

Photocopy of typescript. / Digitized by Kansas Correctional Industries

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published_or_final_version / Industrial Engineering / Master / Master of Science in Engineering