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Human Endogenous Retroviruses (HERV) are segments of the human genome that are viral in origin and occupy approximately 8% of the human genome, which is nearly 3 times as much as functional protein coding genes (3%). Although most are defective due to accumulation of post insertional mutations, Human Endogenous Retrovirus Type K (HERV-K) retains the ability to produce functional particles and is activated during progression of malignant disease. The resulting proviral products have been associated tumorigenesis through their presumed role in malignant cell production. While therapeutics that focus on HERV-K inhibition have not been manufactured, current Federal Drug Administration (FDA) approved antiretroviral therapies are capable of decreasing expression of HERV-K in cancer cells. In summary, antiretroviral drugs may serve as a promising new anticancer drug by targeting and decreasing expression of HERV-K proteins.

The topic of this diploma thesis is ?The Nurse?s Contribution to the Management of Pain Treatment of Patients with a Malignant Disease?. The first objective is to ascertain whether nurses know the specifics of care of patients suffering from a cancer pain. The second objective is to ascertain whether nurses use an analogue score to assess the cancer pain. The third objective is to ascertain whether nurses document the pain intensity. The fourth objective is to ascertain whether nurses use non-pharmacological techniques to relieve cancer pains. The fifth objective is to ascertain whether nurses know the strategy of the WHO?s pain relief ladder. The research was conducted in the form of questioning while using the technique of anonymous structured questionnaires completed by the research set consisting of nurses in selected clinical wards with a high probability of occurrence of patients with an oncologic diagnosis. The total of 360 questionnaires was distributed, of which 198 completed questionnaires were returned. 105 questionnaires (53 %) came from the regional hospital in České Budějovice, 51 (26 %) from the St. Anne?s University Hospital in Brno and 42 (21 %) from the district hospital in Tábor. The research took place in March 2012. The results were assessed under the criteria preset by the author of the thesis. Hypothesis 1: Nurses are able to provide specific nursing care to patients suffering from a cancer pain, was confirmed. Hypothesis 2: Nurses assess the pain under the available analogue scores, was confirmed. Hypothesis 3: Nurses document the pain intensity, was disconfirmed. Hypothesis 4: Nurses use non-pharmacological techniques, especially physical ones, was confirmed. Hypothesis 5: Nurses know the strategy of the WHO?s pain relief ladder, was confirmed. In connection with the addressed issue, an educational leaflet about pain monitoring was drawn up for non-medical healthcare workers. This material describes the most frequently used methods of pain assessment and will serve as an overview of individual procedures including their specifics and application possibilities. The diploma thesis may serve for extending the knowledge of nurses in the field of pain treatment management.

In worldwide basis, the carcinoma of cervix is the second most frequent malignant tumour in women. There is up to 1200 new cases diagnosed in our country every year. Considering the sad fact that more than 400 women die in our country every year, the battle against the carcinoma of cervix became recently one of the priorities of the Ministry of Health of the Czech Republic. The nationwide screening focused on early detection of cervical cancer was launched in our country in 2008. The dissertation paper entitled ``Awareness of university students of the risk of cervical cancer and its prevention`` is mainly focused on monitoring of awareness of university students of the risk of cervical cancer disease and the possible ways of its prevention. The assessed group was made of university students, young women from South Bohemian and Prague universities. In the research part of the dissertation the author used a method of questioning with the technique of data collection using anonymous questionnaire. The research has revealed that the students have basic knowledge on the issue of cervical carcinoma, namely in the area of risk and prevention. It was also found that the awareness of the students of the South Region on this issue was much better than of the students in the Prague region. Despite the overall positive results, the research shows the need to inform the public especially about the hazards of smoking as a possible risk factor associated with cancer. It is also necessary to expand knowledge of women in already developed symptoms of the disease. There is currently only one known - bleeding after intercourse. In the area of prevention it is also desirable to highlight the availability of some special examinations for men, while appealing to the possibility of lifelong disability as a serious consequence of this disease. Research shows that it is still necessary to inform more and better the public about this issue. From the views of the respondents it is clear that in addition to ads aimed at promoting vaccination, the problems of the disease is poorly presented. This is confirmed by the fact that students do not know any organization focused on this problem. To a good awareness of women in this field, in terms of risks, prevention and possible vaccination, should contribute especially gynaecologists, together with the midwives, because as part of the preventive visits they have the opportunity to address the women and to specifically discuss the issues with them. It is unfortunately evident from the research that these doctors inform minimally about the possible ways of prevention. In my opinion, to respond to the observed facts and to refine and improve the information system for a maximum possible way it is in the interests of all women and girls, whether by improving the own work of gynaecologists, as well as improving awareness about this problem through the media or by using a variety of booklets and leaflets in offices of other physicians, that are currently seen only sporadically.