CHDS State/Local / Approved for public release, distribution is unlimited / As the United States improves its collective awareness and emergency preparedness in the face of increased terrorist activity, more efforts are being made to create and enhance community readiness for catastrophic events. There have been substantial efforts to improve the nation's bioterrorism preparedness. Better planning, equipment, training, surveillance, and pharmaceutical caches have elevated the nation's readiness for biological attacks. In order to effectively meet the challenges created by a bioterrorism attack, its first lines of defense, the first responders, must be rapidly prophylaxed to allow the continuance of their mission. Many states and localities have tackled the gigantic undertaking of mass prophylaxis plans to provide chemoprophylaxis to civilians should the need arise. Many cities have developed and tested their plans to provide general public mass prophylaxis. It is assumed, or briefly mentioned, that the mass prophylaxis of first responders will occur, but few plans have been developed. The primary objective of this research is to develop, test, and make recommendations for a straightforward, adaptable mass prophylaxis plan to meet the prophylactic requirements of local first responders in the event of a biological attack. / Paramedic and Disaster Coordinator, Anaheim Memorial Medical Center, CA