Indiana University-Purdue University Indianapolis (IUPUI) / While optimization techniques have been studied since 300 B.C. when Euclid first considered the minimal distance between a point and a line, it wasn’t until 1966 that location optimization was first applied to a problem in healthcare. Location optimization techniques are capable of increasing efficiency and equity in the placement of many types of services, including those within the healthcare industry, thus enhancing quality of life. Medical imaging is a healthcare service which helps to determine medical diagnoses in acute and preventive care settings. It provides physicians with information guiding treatment and returning a patient back to optimal health. In this study, a retrospective analysis of the locations of current medical imaging centers in central Indiana is performed, and alternate placement as determined using optimization techniques is considered and compared. This study focuses on reducing the drive time experienced by the population within the study area to their nearest imaging facility. Location optimization models such as the P-Median model, the Maximum Covering model, and Clustering and Partitioning are often used in the field of operations research to solve location problems, but are lesser known within the discipline of Geographic Information Science. This study was intended to demonstrate the capabilities of these powerful algorithms and to increase understanding of how they may be applied to problems within healthcare. While the P-Median model is effective at reducing the overall drive time for a given network set, individuals within the network may experience lengthy drive times. The results further indicate that while the Maximum Covering model is more equitable than the P-Median model, it produces large sets of assigned individuals overwhelming the capacity of one imaging center. Finally, the Clustering and Partitioning method is effective at limiting the number of individuals assigned to a given imaging center, but it does not provide information regarding average drive time for those individuals. In the end, it is determined that a capacitated Maximal Covering model would be the preferred method for solving this particular location problem.