Pressure is mounting in the concrete industry to adopt eco-efficient methods to reduce CO₂ emissions. Portland cement (PC), an essential concrete ingredient, is responsible for over two-thirds of the embodied energy of the concrete, generating about 8% of global greenhouse gas emissions. Extraction and transportation of aggregates and raw materials that comprise concrete mixes are also directly linked to their embodied energy; thus, recycled concrete aggregates (RCA) have been proposed as a promising alternative to increase sustainability in new construction. In this context, many studies have been conducted over the past decades on the properties of RCA concrete. Recent studies have shown that suitable fresh (i.e., flowability) and short-term hardened (i.e., compressive strength) properties might be achieved when the unique microstructural features of RCA are accounted for in the mix-design process of the recycled concrete. However, manufacturing RCA from construction demolition waste (CDW) or returned concrete (RC) presents its unique challenges. Amongst others, the variation in the source of RCA and the presence of damage due to several deterioration mechanisms causes major concern. Due to the presence of reactive aggregates in many quarries in Canada, alkali-silica reaction (ASR) is one of the most common deterioration mechanisms. The durability and long-term performance of RCA concrete are not fully understood and should be further investigated, especially in regards to a) the potential of further (secondary) deterioration of recycled concrete bearing coarse and fine alkali-silica reactive aggregates b) the impact of the severity of the initial reaction on mechanical properties and kinetics of expansion in recycled concrete and c) the impact of using sound and alkali-silica reaction (ASR) affected RCA on the chloride diffusivity (and thus corrosion initiation) of concrete. This work aims to appraise the durability performance of RCA concrete made of 100% coarse RCA, particularly two families of RCA selected (i.e., returned concrete RCA, demolished concrete RCA) to represent waste currently being generated. Furthermore, two types of reactive aggregates are selected to investigate the impact of the source of the reaction (i.e. reactive coarse aggregate as original virgin aggregate - OVA and reactive sand within the residual mortar - RM) within the RCA. ASR is the distress mechanism used to introduce damage to the manufactured RCA. A new mix design technique was used to produce recycled concrete mixtures to increase eco-efficiency, improve fresh-state properties, and reduce cement use in RCA concrete. In conclusion, the initial reaction's location and severity significantly impact the compressive strength, SDT parameters, chloride diffusion rate, and shear strength of concrete specimens. Specifically, the location of the initial reaction can influence the distribution and extension of damage within the various parts of recycled concrete, while the severity of the initial reaction can affect the overall integrity of the aggregates as well as the availability of silica and alkalis for secondary reaction. These results demonstrate the importance of assessing the severity of the initial reaction and its source in order to ensure the durability and long-term performance of recycled concrete made with reactive RCA.