Aim: To determine the resources and needs of local Ethics Review Committees in South Western Nigeria. Method: This is a questionnaire-based descriptive study, where data was collected from the chair and administrators of eight Ethics Review Committees (ERCs) in South Western Nigeria. Findings: This study found that six of the ERCs reviewed were established 5 years ago and 75% of them were registered with NHREC. Of the ERCs reviewed, 75% are aware of the national ethics code (NHREC code). The majority of these ERCs (75%) had professionals, including doctors and scientists, as well as laypersons and nonscientists as members. Meetings were held once a month and when needed for 37.5% of the committees, while 25% of the ERCs usually meet every 2 months. Only a third (37.5%) of the ERCs pay their members. The majority (87.5%) of the ERCs have standard operating procedures (SOPs) and review an average of 6–10 or 10 protocols per month. Most of the ERCs (87.5%) need research ethics training regarding risk-benefit assessment, scientific design and HIV vaccine trials. Half of the ERCs reviewed have funding and financial support and 50% charge a fee for reviewed protocols. All the ERCs have computers, office space and stationery, while 50% lack access to a library. None of the committees studied have a bank account and facsimile, while 50% do not have internet access, telephone and photocopy machines Outcome: The majority of ERCs in South Western Nigeria have an adequate number of members, are familiar with international ethics guidelines and are registered with the NHREC. They also have adequate physical resources, but lack internet access and a library. Ongoing training of members is a challenge, as well as providing training programmes for new members and monitoring of research. / Thesis (M.Soc.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2011.