The purpose of this naturalistic inquiry was to understand factors that influence patients’ commitment to colorectal cancer screening, specifically colonoscopy. Fifteen personcentred interviews were conducted: 10 with individuals who had completed screening, and 5 with individuals who declined. Three subthemes (relationship, motivation, and human agency) were associated with the overarching theme of regard or disregard for vulnerability. Participants who perceived a disregard for their vulnerability by their health care provider (HCP) frequently chose to decline screening even though they showed a high level of commitment to health promotion. Participants who perceived a regard for vulnerability by their HCP frequently chose to accept screening. The nursing profession can show a regard for patient vulnerability by enhancing communication techniques and concentrating on being attentive to patient concerns which will build a trusting relationship with patients and enhance screening rates. Persistence in the relationship can change a patient’s decision in time. / 132 leaves : col. ill. ; 29 cm