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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

Effect of Transcatheter Aortic Valve Replacement on Right Ventricular Function| Meta analyses and Systematic Review

Zahaf, Marwah 25 January 2016 (has links)
<p> <b>Objectives:</b> We ought to compare the effect of transcatheter aortic valve replacement (TAVR) and surgical aortic valve replacement (SAVR) on right ventricular systolic function (RVSF) in high risk patients with severe aortic stenosis (AS). <b>Methodology: Data Source</b>. PubMed, EMBASE, Cochrane library, and references of selected articles. Study Endpoints. Transthoracic echocardiography was utilized to assess the change in RVSF post TAVR versus SAVR using tricuspid annular plane systolic excursion (TAPSE), and Fractional area change (RVFAC). <b>Statistical analyses</b>. Random effect model on standardized mean difference (Hedges; g) were used together with heterogeneity assessment. <b>Result:</b> We included 485 patients from five single-center observational studies. Comparing TAVR with SAVR, TAVR resulted in better improvement in RVSF [TAPSE (<i>g</i>=2.88, SE=0.63, <i>P</i>&lt;0.001, Q=73.18, /<sup>2</sup>=94.53, r=0.65), and RVFAC (<i>g</i>=0.91, SE=0.16, <i>P</i>&lt;0.001, Q=2.39, /<sup>2</sup>=16.61), r=0.65]. <b> Conclusion:</b> Compared with SAVR, TAVR is preferred aortic intervention in patients with severe symptomatic AS and RV systolic dysfunction.</p>

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