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The purpose of this study was to test a theoretical model which predicted subjective well-being in patients who had been diagnosed with malignant melanoma. The theoretical model was developed from empirical findings based on a review of the literature in which health locus of control, social support and self-esteem were identified as significant predictors of well-being. The specific aim of this study was to examine the strength of the predicted relationships between selected psychosocial variables and subjective well-being. The study utilized a nonexperimental correlational design with a causal modeling approach. The convenience sample was composed of 75 individuals (x age = 52.5) who had been diagnosed with malignant melanoma. Subjects completed four instruments which measured the theoretical concepts under study. Two additional instruments were administered which indexed the variables of search for meaning and concern of recurrence. Descriptive statistics were used in examining the demographic and situational characteristics of the sample. Multiple regression techniques were utilized to empirically test the predicted theoretical relationships and to estimate predictive validity for the theoretical concepts. Graphic residual analysis was performed to assess for violations in the statistical and causal model assumptions. Study findings revealed that social support had a direct positive impact on self-esteem (B =.27, R² =.06) and that self-esteem had a direct positive impact on well-being (B =.49, R² =.37). The two demographic variables of employment and income were found to have a direct positive impact on well-being (B =.22 and B =.26, respectively), and resulted in a 10% increase in the total explained variance in well-being. The theoretical model, which was generated to predict subjective well-being in malignant melanoma patients, explained 47% of the total variance in well-being. Research into the variables which influence patient well-being during the cancer experience is vital if nursing is to implement therapeutic interventions which will promote an improved life quality. By intervening with nursing actions that focus on a positive self-esteem, a greater sense of well-being could be attained by individuals diagnosed with cancer.