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Mechanismy imunitní odpovědi při léčbě rakoviny kotvením ligandů fagocytárních receptorů na povrch nádorových buněk / Mechanisms of the immune response during the cancer treatment with ligands of phagocytic receptors anchored to the surface of malignant cellsAUEROVÁ, Marie January 2014 (has links)
The aim of this thesis was to obtain some insights into mechanisms by which the immune system affects melanoma cells after anchoring agonists of phagocytic receptors (laminarin and f-MLF) to their surface. To verify the hypothesis that innate immune system plays a critical role, in vivo experiments were performed on SCID mice. To elucidate the importance of CR3, CD11b-deficient mice were used. In in vitro experiments production of inflammatory cytokines in tumor tissue was examined as well as the release of myeloperoxidase from neutrophil granules after incubation with malignant cells.
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Exploring anti-tyrosinase bioactive compounds from the Cape floraSonka, Luveni January 2018 (has links)
>Magister Scientiae - MSc / Tyrosinase is an enzyme widely distributed in the biosphere and is found in many species of
bacteria, fungi, animals, and plants; it is associated with melanin production. Even though it
possesses many beneficial properties such as photoprotection, but overproduction causes
undesirable effects such melasma, solar lentigines etc. Therefore, tyrosinase enzyme inhibitors
are of far-ranging importance in cosmetics, medicinal products, and food industries.
This study is aimed to test anti-tyrosinase activity in 37 plants from 20 families using
mushroom tyrosinase inhibition method; each plant was extracted with methanol. The results
showed that 17 plant extracts, exerted a considerable level of in vitro tyrosinase inhibition
comparable to positive controls of kojic acid in the same solvent systems when evaluated
spectrophotometrically. Among plant extracts, those that showed an inhibition rate >50 % at
50 μg/ml and ˃60 % at 200 μg/ml were A. karroo (Hayne.), A. afra Jacq. Ex Willd, C.
geifolia (L.), E. racemosa (L.), H. petiolare Hilliard & B.L.Burt, M. quercifolia (L.), M.
communis (L.), P. rigida (Wikstr.), P. ecklonii (Benth.), P. ericoides (L.), S. Africanacaerulea
(L.), S. Africana-lutea (L.), S. antarcticus (Willd.), S. lucida (L.) F.A.Barkley, S.
hamilifolius (L.), S. furcellata R.Br and T riparia which exhibited great anti-tyrosinase
activity.
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Studium mechanismů působících při nádorové imunoterapii založené na instalaci ligandů fagocytárních receptorů na povrch nádorových buněkSVÁČKOVÁ, Denisa January 2016 (has links)
The aim of thesis was to study murine melanoma B16- F10 therapy based on the use of TLR agonists combinedwith activation of phagocytosis. Mechanisms of this therapy were studied on the bases of analysis of tumor infiltrating immune cells and evaluationof thein effect on tumor cells.
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Studium klinicky aplikovatelné nádorové imunoterapie a jejich mechanismů / Study of clinically applicable cancer immunotherapy and their mechanismsGLASEROVÁ, Simona January 2015 (has links)
The aim of this thesis was study of replacement of LPS in innate immunity based cancer immunotherapy. Application of poly (I:C) with mixture of mannan-SMCC + R-848.HCl leads to synergy, higher reduction of tumor growth and significant prolongation of survival. The significance and mechanism of action of neutrophils have also been studied within this therapy.
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MEDICINAL BENEFITS OF SEA CUCUMBERS FROM THE WATERS OF THE EASTERN UNITED STATESEaint Honey Aung Win (13163001) 27 July 2022 (has links)
<p>Sea cucumbers have been found to contain bioactive compounds such as saponin, fucoidan, frondoside, and glycosides that have pharmacological properties like antitumor, antibacterial, anti-inflammation, and antihyperglycemic activity. Although several species of sea cucumbers have been studied and reared for the food and medicinal industries, not much research has been conducted on the species in the waters of the Eastern United States. In this research, physiological and immunological parameters of coelomic fluid from <em>Cucumaria</em> <em>frondosa</em>, <em>Isostychopus</em> <em>badionotus</em>, and <em>Pentacta</em> <em>pygmaea</em> were compared to find the most promising candidate with these properties and pharmacological benefits. We found that <em>C. frondosa</em> was the species with the best immunological and physiological parameters among the three studied. <em>C. frondosa</em> illustrated that its coelomic fluid contains the highest concentrations of cells and lysozymes that had the highest activity. Using <em>C. frondosa</em>’s tissue extracts and coelomic fluid, the ability of the extracts and coelomic fluid to inhibit murine melanoma cells (B16-F10) and modulate T-lymphocytes <em>in vitro</em> were investigated. Although no significant differences were seen statistically, the experiments illustrated that T-lymphocytes were highly activated at higher concentrations (0.001g/uL-0.0002g/uL) for tissue extracts and at lower concentrations (0.000008g/uL) for coelomic fluid. On the other hand, melanoma cells were inhibited highest at lower concentrations (0.000008g/uL-0.0000016/uL). In addition to these studies, the antibacterial activity of <em>C. frondosa</em> extract was tested on ten pathogenic bacterial species. Antibacterial activity of the <em>C. frondosa</em> extract was not seen in this experiment. However, hemolytic activity by compounds present in <em>C. frondosa</em> extracts was seen in blood agars culturing <em>Streptococcus pneumoniae</em> and <em>Enterococcus faecalis</em> in our experiment. Lastly, an <em>in vivo </em>study was conducted to see if <em>C. frondosa</em> extract can modulate stress in Nile tilapia. In our experiment, we observed that <em>C. frondosa</em> extract was able to enhance the activity of one of the parameters, phagocytic capacity significantly. However, we are not able to conclude that <em>C. frondosa</em> extract was able to mitigate chronic stress from the results obtained. Overall, observing the results from the projects, we cannot conclude that <em>C. frondosa</em> extracts illustrated pharmacological properties. Extensive studies are recommended and required to use <em>C. frondosa</em> extract for medicinal purposes. </p>
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