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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
21

The Effect of Styrene-Maleic Acid (SMA) Copolymers on Solubilizing Lipid Bilayers and Forming Nanodiscs

Alramadan, Ghada 20 December 2018 (has links)
Cell membranes, or plasma membranes, play an essential role in the structure and the function of living cells. In 1972, the fluid mosaic membrane model was the first unifying paradigm of membrane structure. It is no longer considered adequate because evidence of many non-homogeneous lipid structures in both natural and model membranes have been discovered over the past thirty years. The field of membrane biophysics now uses updated versions of the mosaic model, which consists of the complex mixture of different lipid species. The lipid species found in natural membranes produce a range of dynamic, laterally segregated, non-homogeneous domains, which exist on time scales ranging from microseconds to minutes. The cell membrane is an enclosing or separating membrane that acts as a selectively permeable barrier within living things. It consists of the phospholipid bilayer with associated embedded proteins, integral (intrinsic) and peripheral (extrinsic) proteins used for various biological activities. Proteins, especially integral membrane proteins, perform a range of key functions vital to the cell, such as controlled movement of molecules across lipid bilayers, as well as participating in cell signaling and motility. The major obstacle to studying membrane proteins is the tendency for some of their properties to change and the proteins themselves may be denatured when extracted by detergents. One of the most significant approaches to solve this problem is the use of styrene-maleic acid copolymers (SMAs), which offers detergent-free solubilization of embrane, which allows studies of membrane proteins to be done in very small systems. The main goal of this thesis is to examine the effects of these polymers on the interior of the lipid bilayer. With these, membrane proteins can be extracted from cell membranes while conserving a patch of near-native membrane around them. It has been suggested but not proven that proteins in nanodiscs reside in a hydrophobic environment that is identical to that found in the native cell membrane. Moreover, I also investigate the kinetics of membrane solubilization by SMA by using UV/visible spectrophotometer. In addition, I examine how lipid packing in the nanodiscs is affected by the presence of the polymers and how it depends on polymer composition by using SMA variants with different styrene-to-maleic acid ratios.
22

Synthesis, purification and characterization of the second transmembrane domain of Crep-1, Tm-B and effects of polyunsaturated phospholipids (plipc) and cholesterol on the alignment temperature and fluidity of magnetically aligned DMPC/DHPC phospholipid bilayers

Adhikari, Prem R. January 2003 (has links)
Thesis (M.S.)--Miami University, Dept. of Chemistry and Biochemistry, 2003. / Title from first page of PDF document. Document formatted into pages; contains ix, 87 p. : ill. Includes bibliographical references (p. 85-87).
23

MEMBRANE ACTIVE COMPOUNDS IN BARLEY ROOT ULTRASTRUCTURE

Fox, Richard H. (Richard Henry), 1938- January 1966 (has links)
No description available.
24

The modulation of protein kinase C by hydration and membrane spontaneous curvature /

Giorgione, Jennifer. January 1999 (has links)
Thesis (Ph.D.) -- McMaster University, 1999. / Includes bibliographical references (leaves 214-223). Also available via World Wide Web.
25

Characterization of membrane viscosity changes with the novel molecular rotor FCVJ

Nipper, Matthew Edward. January 2007 (has links)
Thesis (M.S.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on May 12, 2009) Includes bibliographical references.
26

Ratiometric techniques to determine fluid viscosity using molecular rotors

Shuaib, Ali. January 2007 (has links)
Thesis (M.S.)--University of Missouri-Columbia, 2007. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on May 12, 2009) Includes bibliographical references.
27

Mass transfer analysis of polyether sulfone and polyamide membranes modified by ion beam irradiation /

King, Stanley W. January 2004 (has links)
Thesis (M.S.C.)--University of Toledo, 2004. / Typescript. "A thesis [submitted] as partial fulfillment of the requirements of the Master of Science degree in Chemical Engineering." Bibliography: leaves 109-113.
28

A molecular study of membrane structure in liposomes /

Chen, Changfeng, January 2009 (has links)
Thesis (Ph.D.) in Chemistry--University of Maine, 2009. / Includes vita. Includes bibliographical references (leaves 144-162).
29

Nanoscale imaging and spectroscopy of membrane organization /

Gould, Travis John, January 2009 (has links)
Thesis (Ph.D.) in Physics--University of Maine, 2009. / Includes vita. Includes bibliographical references (leaves 129-144).
30

Transmembrane electron transfer in artificial bilayers /

Lee, Lester Y. C., January 1985 (has links)
Thesis (Ph. D.)--Oregon Graduate Center, 1985.

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