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Stabilisation of metastable polymorphs: the case of paracetamol form IIITelford, Richard, Seaton, Colin C., Clout, A., Buanz, A.B.M., Gaisford, S., Williams, G.R., Prior, T.J., Okoye, C.H., Munshi, Tasnim, Scowen, Ian J. 05 August 2016 (has links)
Yes / The design of a melt synthesis of the first air-stable formulation of the metastable form III of paracetamol is derived from thermo-spectroscopic and thermo-diffraction experiments. Melt crystallisation in the presence of β-1,4-saccharides produces form III selectively and the excipients appear to act as stabilising ‘active’ templates of the metastable polymorph. / This article is part of themed collection: Pharmaceutical Solids.
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