Thesis (M.S.)--University of Wisconsin--Madison, 1962. / Typescript. eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 94-98).

Thesis (Ph. D.)--Leland Stanford Junior University, 1913. / Cover title. "Reprinted from the Journal of the American chemical society, vol. XXVIII. no. 10. October, 1906." 16 blank pages for notes at end.

Thesis (Ph. D.)--Ohio State University, 2007. / Full text release at OhioLINK's ETD Center delayed at author's request

Thesis (Ph. D.)--Princeton University, 1924.

No description available.

Lee, Chi-wai. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 124-145). / Abstract also in Chinese. / Declaration --- p.i / Acknowledgements --- p.ii / Abstract --- p.iii / 槪要 --- p.v / Contents --- p.vii / List of Figures --- p.xi / List of Tables --- p.xiv / List of Abbreviations --- p.xvi / Chapter Chapter 1 --- Introduction --- p.1 / Chapter 1.1 --- Overview of pharmacogenetics --- p.2 / Chapter 1.2 --- Clinical importance of nitrogen oxidations --- p.8 / Chapter 1.3 --- Characteristics of trimethylamine (TMA) --- p.9 / Chapter 1.4 --- Genetic polymorphism of trimethylamine N-oxidation --- p.12 / Chapter 1.5 --- Enzyme systems mediating trimethylamine N-oxidation --- p.15 / Chapter 1.6 --- Aims and objectives --- p.19 / Chapter Chapter 2 --- Development of an Analytical Method for Trimethylamine & Trimethylamine N-Oxide --- p.20 / Chapter 2.1 --- Introduction --- p.21 / Chapter 2.2 --- Materials --- p.26 / Chapter 2.3 --- Methods --- p.27 / Chapter 2.3.1 --- Preparation of stock solutions --- p.27 / Chapter 2.3.2 --- Preparation of GLC glass column --- p.28 / Chapter 2.3.3 --- Optimizing GLC conditions for the separation of trimethylamine --- p.29 / Chapter 2.3.4 --- Sample pretreatment for GLC analysis --- p.29 / Chapter 2.3.5 --- Construction of calibration curve --- p.31 / Chapter 2.3.6 --- Determination of the required amounts of titanium (III) chloride for trimethylamine N-oxide reduction --- p.31 / Chapter 2.3.7 --- Intra- and inter-assay variations --- p.31 / Chapter 2.3.8 --- "Equations used in the determinations of free TMA, total TMA, and percentage TMA excreted as TMAO" --- p.32 / Chapter 2.3 --- Results --- p.33 / Chapter 2.3.1 --- GLC chromatogram --- p.33 / Chapter 2.3.2 --- Construction of calibration curve --- p.33 / Chapter 2.3.3 --- Determination of the required amounts of titanium (III) chloride for trimethylamine N-oxide reduction --- p.33 / Chapter 2.3.4 --- Intra- and inter-assay variations --- p.37 / Chapter 2.4 --- Discussion --- p.37 / Chapter Chapter 3 --- Trimethylamine N-Oxidation in Chinese --- p.41 / Chapter 3.1 --- Introduction --- p.42 / Chapter 3.2 --- Experimental protocols --- p.43 / Chapter 3.2.1 --- Whole day urine collections --- p.43 / Chapter 3.2.2 --- Spot urine collections --- p.44 / Chapter 3.3 --- Results --- p.44 / Chapter 3.3.1 --- Whole day urine collections --- p.44 / Chapter 3.3.2 --- Spot urine collections --- p.46 / Chapter 3.3.3 --- Comparison between whole day urine collections and spot urine collections protocols --- p.50 / Chapter 3.3.4 --- Comparison between smokers and non-smokers --- p.52 / Chapter 3.3.5 --- Comparison the results obtained in between four individual periods of whole day urine collections --- p.52 / Chapter 3.4 --- Discussion --- p.56 / Chapter Chapter 4 --- Effect of Age and Diet on Trimethylamine N-oxidation --- p.64 / Chapter 4.1 --- Introduction --- p.65 / Chapter 4.2 --- Experimental protocols --- p.73 / Chapter 4.2.1 --- Effect of age on TMA N-oxidation --- p.73 / Chapter 4.2.2 --- Effect of diet on TMA N-oxidation --- p.73 / Chapter 4.2.3 --- Effects of control diet on TMA N-oxidation --- p.75 / Chapter 4.3 --- Results --- p.76 / Chapter 4.3.1 --- Effect of age on TMA N-oxidation --- p.76 / Chapter 4.3.2 --- Effect of diet on TMA N-oxidation --- p.80 / Chapter 4.3.3 --- Effects of control diet on TMA N-oxidation --- p.83 / Chapter 4.4 --- Discussion --- p.89 / Chapter Chapter 5 --- Effect of Disease on Trimethylamine N-Oxidation --- p.101 / Chapter 5.1 --- Introduction --- p.102 / Chapter 5.2 --- Experimental protocols --- p.108 / Chapter 5.3 --- Results --- p.109 / Chapter 5.4 --- Discussion --- p.116 / Chapter Chapter 6 --- General Discussion --- p.119 / References --- p.124 / Appendices / Chapter Appendix A / Chapter A.1 --- Sample record sheet for food intake and activity (English) --- p.A-l / Chapter A.2 --- Sample record sheet for food intake and activity (Chinese) --- p.A-3 / Chapter Appendix B --- Food intake and activity record for volunteer Ain controlled diet experiment --- p.B-1

Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 183-205).

A novel technique comprising solid phase microextraction and gas chromatography has been developed to analyse the three methylamines (monomethylamine, dimethylamine and trimethylamine) at the concentrations expected in seawater. The volatility of the methylamines was exploited and allowed the headspace pre-concentration and gas chromatographic separation of the analytes. This method achieved limits of detection of 0.43 nmol dm-3, 2.50 nmol dm-3 and 0.37 nmol dm-3 for monomethylamine, dimethylamine and trimethylamine, respectively, which are lower than any previously reported for seawater. This technique was applied to natural samples collected from the Western English Channel (WEC) and the methylamines were successfully quantified. A liquid chromatography-mass spectrometry method was used to analyse glycine betaine in marine particulates. The volume filtered during sample collection was found to be critical in achieving accurate measurements of glycine betaine. Large filter volumes (1 L) significantly decreased observed concentrations compared to smaller volumes, and 10 mL was the optimised amount filtered. The difference in concentrations was attributed to large water volumes causing cell damage and loss of glycine betaine to the dissolved phase. Cell resilience was thought to play a role in the differences observed; for example, diatoms with their rigid silica cell walls were hypothesised to be more resilient to filtration stress. A seasonal study was carried out in the WEC using both 1 L and 10 mL samples and maximum glycine betaine concentrations were 50 nmol dm-3 and 484 nmol dm-3 in the 1 L and 10 mL samples, respectively. The latter concentrations were more than an order of magnitude higher than all previous measurements. Seasonality was observed and a significant correlation was found with chlorophyll a. Statistics were applied to the phytoplankton biomass data and contributions from specific phytoplankton taxa were identified, including from Prorocentrum minimum and Chaetoceros socialis.