Global ETD Search

31	Renal calcification in Npt2 knockout mice Chau, Hien Nguyet, 1977- January 2002 (has links) Mice homozygous for the disrupted renal type 11a sodium/phosphate (Na/Pi) cotransporter gene, Npt2, (Npt2 KO) exhibit renal Pi wasting and hypercalciuria, predisposing factors for renal stone formation. We observed that Npt2 KO mice, but not wild-type littermates form renal stones. The renal stones were evident in newborn, weanling and adult mice and composed of calcium (Ca) and Pi. The presence of renal calcification correlated with the absence of Npt2 gene expression and the presence of genes responsible for the synthesis (1alpha-hydroxylase) and catabolism (24-hydroxylase) of 1,25-dihydroxyvitamin D, whose elevated levels contribute to the hypercalciuria and renal calcification in Npt2 KO mice. The renal calcification was associated with increased osteopontin (OPN) mRNA expression and colocalized with OPN, the latter associates with renal stones in vivo and inhibits Ca mineralization in vitro). These data demonstrate that hyperphosphaturia and hypercalciuria, secondary to Npt2 gene disruption, are sufficient for the development of renal calcification. Kidneys -- Calculi -- Genetic aspects. Hypercalciurea -- Genetic aspects. Sodium cotransport systems. Osteopontin. Mice -- Molecular genetics.
32	Transcriptional activity of sex chromosomes in the oocytes of the B6.Ytir sex-reversed female mouse Nasseri, Roksana. January 1998 (has links) In the B6.YTIR mouse strain, half of the XY progeny develop bilateral ovaries and the female phenotype. These XY females are infertile mainly due to the death of their embryos. This developmental failure has been attributed to a defect intrinsic to the XY oocyte. / The present study examined the transcriptional activity of the X and Y chromosomes in these oocytes. RT-PCR results show that the Ube1y gene is transcribed in the XY ovary at all stages examined and also in growing XY oocytes. The Sry gene was transcribed only at the onset of ovarian differentiation whereas the Zfy gene was undetectable at all stages during fetal life. The Xist gene, which is involved in X inactivation, was not expressed in XY oocytes. We speculate that expression of Y-encoded genes may have a deleterious effect on the quality of the oocytes and thus renders them incompetent for post-fertilization development. Sex determination, Genetic Sex chromosomes Mice -- Molecular genetics Sex differentiation disorders
33	Renal calcification in Npt2 knockout mice Chau, Hien Nguyet, 1977- January 2002 (has links) No description available. Sodium cotransport systems. Osteopontin. Mice -- Molecular genetics. Kidneys -- Calculi -- Genetic aspects. Hypercalciurea -- Genetic aspects.
34	Transcriptional activity of sex chromosomes in the oocytes of the B6.Ytir sex-reversed female mouse Nasseri, Roksana. January 1998 (has links) No description available. Sex determination, Genetic Sex differentiation disorders Sex chromosomes Mice -- Molecular genetics
35	The liver phenotype of the aromatase knockout (ArKO) mouse Hewitt, Kylie N. January 2003 (has links) Abstract not available Estrogen -- Receptors Aromatase Cholesterol -- Metabolism Triglycerides -- Metabolism Liver -- Diseases Fatty liver Fatty degeneration Phenotype Mice -- Molecular genetics
36	Characterisation of gene structure and function of the ETS transcription factor Gabpα in mouse O'Leary, Debra Alison January 2003 (has links) Abstract not available DNA-binding proteins Messenger RNA Myoneural junction Embryology Striated muscle -- Physiology Transcription factors Gene expression Genetic regulation Nicotinic receptors Acetylcholine -- Receptors Muscle hypotonia Oxidation-reduction reaction Mice -- Molecular genetics Transgenic mice -- Embryology

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