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Fabrication and characterization of dexibuprofen nanocrystals using microchannel fluidic reactorKhan, J., Bshir, S., Khan, M.A., Mohammad, Mohammad A., Isreb, Mohammad 06 November 2019 (has links)
Yes / Purpose: Dexibuprofen is an enantiomer of ibuprofen with low bioavailability which results
from its hydrophobic nature. Nanosuspensions have developed a podium to solve the in vitro
dissolution problem that frequently occurs in current research.
Materials and methods: The drug and polymer solutions were mixed in a microchannel
fluid reactor and the successive embryonic nanosuspension was decanted into a vial having the
polymer solution. The impact of different process and formulation parameters including inlet
angle, antisolvent and solvent flow rate(s), mixing time, drug concentration, polymer type and
concentration was evaluated.
Results and discussion: Stable dexibuprofen nanocrystals with a particle size of 45±3.0 nm
and polydispersity index of 0.19±0.06 were obtained. Differential scanning calorimetry and
powder X-ray diffraction confirmed the crystallinity. The key parameters observed were inlet
angle 10°, antisolvent to solvent volume of 2.0/0.5 mL/min, 60 minutes mixing with 5 minutes
sonication, Poloxamer-407 with a concentration of 0.5% w/v and drug concentration (5 mg/mm).
The 60-day stability studies revealed that the nanocrystals were stable at 4°C and 25°C. The
scanning electron microscopy and transmission electron microscopy images showed crystalline
morphology with a homogeneous distribution.
Conclusion: Stable dexibuprofen nanocrystals with retentive distinctive characteristics and
having marked dissolution rate compared to raw and marketed formulations were efficiently
fabricated. In future perspectives, these nanocrystals could be converted to solid dosage form
and the process can be industrialized by chemical engineering approach
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