<p> </p> <p>Moore’s law is dead. The physical and economic principles that enabled an exponential rise in transistors per chip have reached their breaking point. As a result, High-Performance Computing (HPC) domain and cloud data centers are encountering significant energy, cost, and environmental hurdles that have led them to embrace custom hardware/software solutions. Single Instruction Multiple Thread (SIMT) accelerators, like Graphics Processing Units (GPUs), are compelling solutions to achieve considerable energy efficiency while still preserving programmability in the twilight of Moore’s Law.</p> <p>In the HPC and Deep Learning (DL) domain, the death of single-chip GPU performance scaling will usher in a renaissance in multi-chip Non-Uniform Memory Access (NUMA) scaling. Advances in silicon interposers and other inter-chip signaling technology will enable single-package systems, composed of multiple chiplets that continue to scale even as per-chip transistors do not. Given this evolving, massively parallel NUMA landscape, the placement of data on each chiplet, or discrete GPU card, and the scheduling of the threads that use that data is a critical factor in system performance and power consumption.</p> <p>Aside from the supercomputer space, general-purpose compute units are still the main driver of data center’s total cost of ownership (TCO). CPUs consume 60% of the total data center power budget, half of which comes from the CPU pipeline’s frontend. Coupled with the hardware efficiency crisis is an increased desire for programmer productivity, flexible scalability, and nimble software updates that have led to the rise of software microservices. Consequently, single servers are now packed with many threads executing the same, relatively small task on different data.</p> <p>In this dissertation, I discuss these new paradigm shifts, addressing the following concerns: (1) how do we overcome the non-uniform memory access overhead for next-generation multi-chiplet GPUs in the era of DL-driven workloads?; (2) how can we improve the energy efficiency of data center’s CPUs in the light of microservices evolution and request similarity?; and (3) how to study such rapidly-evolving systems with an accurate and extensible SIMT performance modeling?</p>