Thesis (M.Sc.) -- University of Adelaide, Dept. of Human Physiology and Pharmacology, 1976. / Typescript (photocopy).

The influence of peripubertal exposure to physiological levels of testosterone on the adult androgen responsiveness of the cytochrome P450 enzyme activity, hepatic microsomal erythromycin demethylase activity, was investigated. Rats were injected subcutaneously with testosterone enanthate 5 µmoles/kg/day either peripubertally, during adulthood or in both time periods. In adult untreated rats, hepatic microsomal erythromycin demethylase activity was higher in males than in females. Intact adult male rats, but not intact adult female rats, responded to adult testosterone treatment with an increase in hepatic microsomal erythromycin demethylase activity. Female and male rats were gonadectomized before the onset of puberty. In the adult female rats which had been prepubertally ovariectomized, exposure to testosterone peripubertally resulted in an adult androgen responsiveness for hepatic microsomal erythromycin demethylase activity. This indicated that the potential is present in the prepubertally ovariectomized female rat for the pubertal imprinting by testosterone of an adult androgen responsiveness for hepatic microsomal erythromycin demethylase activity. Prepubertal castration of male rats reduced hepatic microsomal erythromycin demethylase activity and plasma testosterone levels from control levels. Hepatic microsomal erythromycin demethylase activity was found to be partially correlated with plasma testosterone levels. The higher hepatic microsomal erythromycin demethylase activity in the adult male rat may therefore be related to high adult male levels of circulating testosterone. The administration of testosterone to adult male rats which had been prepubertally castrated resulted in hepatic microsomal erythromycin demethylase activity which was lower than that of intact males and of intact males treated with testosterone in adulthood. These results indicated that adult androgen responsiveness of hepatic microsomal erythromycin demethylase activity is not completely imprinted in male rats in the neonatal period. This study provided evidence in support of the hypothesis that the peripubertal period is a time during which imprinting by testosterone of adult androgen responsiveness of hepatic P450 enzymes can occur. / Pharmaceutical Sciences, Faculty of / Graduate

This thesis comprises an investigation into the reaction of halogenated xenobiotics and anaesthetic agents, with hepatic microsomal stearate desaturase. The levels of stearate desaturase in the hepatic microsomes were routinely elevated by re-feeding the experimental animals a high carbohydrate diet. The interaction of the xenobiotics with stearate desaturase was assessed by monitoring their effects on the redox steady state of hepatic microsomal cytochrome b₅, in the presence and absence of cyanide.

Diss. (sammanfattning) Stockholm : Karol. inst., 2002. / Härtill 6 uppsatser.

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 128-147).

Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (leaves 126-139).

Thesis (Ph. D.)--University of Alabama at Birmingham, 2007. / Title from first page of PDF file (viewed Feb. 7, 2008). Includes bibliographical references (p. 114-133).

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.

Diss. (sammanfattning) Stockholm : Karol. inst., 2005. / Härtill 4 uppsatser.

Diss. (sammanfattning) Uppsala : Univ., 2002. / Härtill 5 uppsatser.