Neonicotinoid seed treatments are widely used and highly effective against early season insect pests of all row crops throughout the Mid-South region of the United States. An analysis was performed to determine the value of neonicotinoid seed treatments across multiple trials in soybean, Glycine max L.; corn, Zea mays L.; cotton, Gossypium hirsutum L.; and sorghum, Sorghum bicolor L. production systems across the mid-southern region. Neonicotinoid seed treatments provided significant yield and economic increases when utilized the majority of the time. A second experiment was performed to determine the value of various insecticide classes when utilized in an overall systems approach when managing cotton insect pest in the Delta and Hills region of Mississippi. When all classes of insecticides were used in rotation, significant yield and economic benefits were observed in the Delta Region compared to treatment scenarios where some insecticide classes were omitted.