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Thesis (PhD)--University of South Australia, 1997

Thesis (Ph. D.)--University of Wisconsin--Madison, 1968. / Typescript. Vita. Description based on print version record. Includes bibliographical references.

Thesis (M.S.)--University of Wisconsin--Madison, 1966. / eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references.

Doctor of Philosophy / Biochemistry and Molecular Biophysics Interdepartmental Program / John M. Tomich / David L. Wetzel / The technique of near infrared chemical imaging has been widely used for many industrial applications. It offers selectivity and/or sensitivity for numerous organic functional groups. The advantage of the near infrared spectroscopic region is the linear relationship of absorbance and concentration that enables quantitation. This universally employed technique has been a boon for research studies in the industrial process of wheat milling for the production of flour. The milling process has numerous sequential grinding and sieving steps that enable selective physical segregation of a starch rich endosperm product from wheat. Thousands of spectra of purified endosperm and non-endosperm standards are collected to develop a spectral library. Quantitation of the purity of individual processing streams is accomplished by applying a partial least squares calibration that is based upon the spectral library. The quantitative chemical imaging technique is useful for determination of endosperm purity profiles for mill flour streams. These plots reveal purity changes as less pure streams are added to produce a flour blend. The chemical structural basis furthermore allows comparison of purity even with changes in the wheat blend being milled with representative standardization. Furthermore, whereas a certain section of sieves is responsible, for designating the material defined as flour, application of the spectroscopic method is obvious. Select examples of key processing streams were studied to show the possibility of sieve-by-sieve analysis of the physical separation to provide mill optimization. These novel methods of analysis would not be possible without the sensitive and selective method of quantitative chemical imaging. Application of this technique to a few select unit processes is projected to reasonably affect a 1% increase in the yield of high quality flour. This amounts to a significant financial gain against low profit margins.

The thesis deals with the design and production technology of the front hub for a mountain bike. The research focuses primarily on the various control systems of CNC machining apparatuses. The second chapter is devoted to the elemental differentiation of hubs, the concept of personal design of the hub, and the characteristics of the materials for its production and its verification using the FEM analysis. The third chapter deals with the design of a workpiece, instruments and the manufacturing process itself. The design of an NC program constructed in the SinuTrain 4.8. software is dealt with in the fourth chapter. The last part is devoted to the technical and economic evaluation of the proposed solution.

The diploma thesis deals with technological preparation of the production at a CNC machining center, equipped with FANUC control system. In cooperation with company AB KOMPONENTY s.r.o. has been used CAM software GibbsCAM and its extensions VoluMill. The first chapter is devoted to the basic properties of aluminum, aluminum alloys and their using in the industry. Furthermore, the chip foramtion in milling is analysed. The following is an analysis of trochoidal milling and research of CAM systems VoluMill and iMachining - systems based on a medium thickness of chip in rough milling opeartions. Next part deals with the design production process of the selected component, the choice of the blank and the processing of the control program with the VoluMill method for this component. The last chapter of the thesis is focused on the techno-economic evaluation for a given number of pieces and individual production technology.

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Charles University, Faculty of Pharmacy in Hradci Králové Department of: Pharmaceutical Technology Supervisor: Assoc. Prof. PharmDr. Zdenka Šklubalová, Ph.D. Consultant: Mgr. Jana Brokešová Student: Andrea Suther Bunes Title of Thesis: Study of influence of hydrophilic carriers on the dissolution rate of a BCS II drug The aim of this thesis was to study the effect of mixing and co-milling with hydrophilic carriers on the dissolution rate of a model BCS II drug meloxicam. The mixtures of two different drug loads (1-1, 1-8) were characterized for granulometric and dissolution parameters. USP-4 apparatus assembled with a flow-through powder cell (an open loop) was used to estimate meloxicam relative dissolution rate rrel (min-1 ). Mixing with lactose, particularly in a higher ratio, increased the relative dissolution rate in comparison to the pure meloxicam. The effect was further increased by co-milling, but an unfavourable event of agglomeration occurred, especially for the 1-1 drug-excipient ratio sample. Adding chitosan solved this problem due to the formation of interactive mixture. The co-milled sample containing chitosan and lactose in a 1-8 ratio showed the highest rrel = 0.48 min-1 .