We present an analysis of new and published data on P/2013 R3, the first asteroid detected while disintegrating. Thirteen discrete components are measured in the interval between UT 2013 October 01 and 2014 February 13. We determine a mean, pair-wise velocity dispersion among these components of Delta nu = 0.33. +/- 0.03 ms(-1) and find that their separation times are staggered over an interval of similar to 5 months. Dust enveloping the system has, in the first observations, a cross-section of. similar to 30 km(2) but fades monotonically at a rate consistent with the action of radiation pressure sweeping. The individual components exhibit comet-like morphologies and also fade except where secondary fragmentation is accompanied by the release of additional dust. We find only upper limits to the radii of any embedded solid nuclei, typically similar to 100-200 m (geometric albedo 0.05 assumed). Combined, the components of P/2013 R3 would form a single spherical body with a. radius of less than or similar to 400 m, which is our best estimate of the size of the precursor object. The observations are consistent with rotational disruption of a weak (cohesive strength of similar to 50 to 100 N m(-2)) parent body, similar to 400 m in radius. Estimated radiation (YORP) spin-up times of this parent are. less than or similar to 1 Myr, shorter than the collisional lifetime. If present, water ice sublimating at as little as 10-3 kg s(-1) could generate a torque on the parent body rivaling the YORP torque. Under conservative assumptions about the frequency of similar disruptions, the inferred asteroid debris production rate is greater than or similar to 10(3) kg s-1, which is at least 4% of the rate needed to maintain the Zodiacal Cloud.

Hubble Space Telescope observations of active asteroid 324P/La Sagra near perihelion show continued mass loss consistent with the sublimation of near-surface ice. Isophotes of the coma measured from a vantage point below the orbital plane are best matched by steady emission of particles having a nominal size. of. a similar to 100 mu m. The inferred rate of mass loss, dM(d)/dt similar to 0.2 kg s(-1), can be supplied by sublimation of water ice in thermal equilibrium with sunlight from an area as small as 930 m(2), corresponding to about 0.2% of the nucleus surface. Observations taken from a vantage point only 0.degrees 6. from the orbital plane of 324P set a limit to the velocity of ejection of dust in the direction perpendicular to the plane, V-perpendicular to < 1 m s(-1). Short-term photometric variations of the near-nucleus region, if related to rotation of the underlying nucleus, rule-out periods <= 3.8 hr and suggest that rotation probably does not play a central role in driving the observed mass loss. We estimate that, in the previous orbit, 324P lost about 4 x 10(7) kg in dust particles, corresponding to 6 x 10(-5) of the mass of a 550 m spherical nucleus of assumed density rho = 1000 kg m(-3). If continued, mass loss at this rate would limit the lifetime of 324P to similar to 1.6 x 10(4) orbits (about 10(5) years). To survive for the 100-400 Myr timescales corresponding to dynamical and collisional stability requires a duty cycle of 2 x 10(-4) <= f(d) <= 8 x 10(-4). Unless its time in orbit is overestimated by many orders of magnitude, 324P is revealed as a briefly active member of a vast population of otherwise dormant ice-containing asteroids.

Resumé Author of this thesis deals with legal analysis of a status of a minor in the case of disrepair of its family. The thesis is composed of seven chapters, each of them dealing with different aspects of Czech regulation of the relationship between parents and their minor children. First chapter is an introduction and defines legal term of marriage and legal term of a minor child used in the thesis. Second chapter analyses termination of marriage due to death. The chapter is divided into two parts. First part examines relevant Czech legislation engaged in death of natural person. Second part is dedicated to a destiny of orphaned minor. Primary theme of this part is to analyse legal institute of wardship of a minor. Third chapter deals with dissolution of marriage by divorce and Czech regulation of the relationship between divorced parents and their minor children. The aim of this chapter is to analyze statutory conditions and consequences of divorce. The author states two forms of divorce, each of them requires different conditions. The end of the part focuses on judgement of court for the upbringing and support of a minor. Fourth chapter explores forms of raising of a minor. In this chapter author focuses on legal requirements for parents to get the child to the custody. Fifth chapter is about duty of...

This Master's thesis describes the position of a minor debtor in enforcement proceedings. The aim of this thesis it to, first, provide with a complex summary of the issue, concerning primarily topical questions which are discussed by experts in connection with childrens' indebbtedness, and second, to further identify the key drawbacks regarding the enforcement proceedings against minor debtors, with an offer for a solution. The thesis is subdivided into two parts. In the first part, there is the notion of a minor defined - for the purposes of this text, a minor is a person who is younger than eighteen years old and, concurrently, who was not emancipated by a court. The following chapters describe the protection of a minor in the legal system in general, where there are principles of best interest of a child and the right of a child to be respected in their opinion described. Further, the procedural protection of a minor is discussed, concerning primarily the procedural specifics of trials where a minor is a party to the case, including enforcement proceedings. Proper representation of a minor and provision of information to minors is emphasized within the chapter. At the very beginning of the second part, enforcement proceedings is described, and then the particulars of this proceedings are...

LEGAL ASPECTS OF PROVIDING HEALTH CARE TO MINORS This thesis deals with the legal aspects of providing health care to minors in the Czech Republic and in Ireland, and compares the approach to regulation. Regulation of healthcare has undergone a significant change since the ratification of the Convention on Human Rights and Biomedicine. The traditional notion of the doctor-patient relationship as a paternalistic relationship has been abandoned and replaced by an equal relationship - partnership. This change culminated in the adoption of the Health Services Act as well as in other laws adopted in the framework of the reform of health care law. The adoption of the Civil Code could be seen as the final contribution in the discussion of the doctor-patient relationship. The Civil Code includes provisions regulating health care treaty, as a named type of a contract, leaving no doubt about the private-law nature of the doctor-patient relationship. The relationship between the Civil Code and the Act on the Provision of Health Services is complicated and requires the principle called lex specialis derogat generali to be applied. However, for the correct application of this principle it should be remembered that the Civil Code provisions are in some cases very detailed and that some provisions of the Civil...

Natural and synthetic heterocyclic cations that bind to the DNA minor groove have demonstrated effectiveness as therapeutic agents for cancer, parasitic and viral diseases, as well as powerful probes for use to extend our fundamental understanding of DNA molecular recognition. Crystal and NMR structures with a variety of minor groove binding compounds have shed light on the structural varieties of these systems, the important solvent molecules in the complexes, and the induced fit effects for binding of both DNA and the bound small molecule. Topics of specific importance in DNA recognition are the development of a greater variety of cell-permeable minor groove agents that have increased DNA binding sequence selectivity. In this dissertation, the structural and energetic basis of the interaction between DNA and minor groove binders has been systematically investigated. A set of powerful and complementary biophysical methods have been used: gel electrophoresis with ligation ladder assay, circular dichroism, mass spectrometry, surface plasmon resonance and isothermal titration calorimetry have been applied to determine the binding stoichiometry, binding affinity, kinetics and thermodynamics, and also the structural influence that minor groove binders can have on DNA. The results of several minor groove complexes clearly show that based on DNA sequences, minor groove binders can have multiple binding modes and consequently affect the geometry of DNA minor groove and the overall DNA curvature in distinct manners. In addition, the binding enthalpy of a minor groove binder is essentially salt concentration and binding mode independent. Besides the investigation of DNA-minor groove binder complex, the binding and inhibition of transcription factor PU.1 has also been studied. The highly positive charged PU.1 targets DNA by inserting an α-helix in the major groove of the 5’-GGAA-3’ site, and displays a strong salt concentration dependency. A set of minor groove binders have been rationally designed based on the high-affinity DNA sequence for PU.1 to target the flanking sequences of the 5’-GGAA-3’ site. They display a structure-related PU.1 inhibition efficacy. This work demonstrates that minor groove binders are capable of modulating PU.1 by targeting the opposite groove and supports future efforts to develop agents for other transcription factors.

Interval minors of binary matrices were introduced by Jacob Fox in the study of Stanley-Wilf limits. We study what can be implied from their relation to the theory of pattern avoidance of submatrices, which is a very popular area of discrete mathematics. We start by characterizing matrices avoiding small interval minors. We then consider classes of matrices closed under interval minors and we find classes of matrices that cannot be described by a finite number of forbidden interval minors. We also define and study a variant of a classical extremal Tur'an- type question studied in the area of combinatorics of permutations and binary matrices and in combinatorial geometry. 1

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In order to investigate the stylistic transformation that occured before Bruckner abandoned the composition of Masses, this paper analyzes the Credo settings in his last three great Masses, with special attention to the treatment of the text. The relationship between the text and specific musical techniques is also considered. The trends found in these three works, especially in the last setting in F minor, confirm the assumption that Bruckner's Mass composition served as a transition to the composition of his symphonies.