Time-Interleaved Analog to Digital Converters (TI ADC) consist of several individual sub-converters operating at a lower sampling rate, working in parallel, and in a circular loop. Thereby, they are increasing the sampling rate without compromising on the resolution during conversion, at high sampling rates. The latter is the main requirement in the area of radio frequency sampling. However, they suffer from mismatches caused by the different characteristics in each sub-converter and the TI structure. The output of the TI ADC under consideration contains a lot of harmonics and spurious tones due to the non-linearities mismatch between the sub-converters. Therefore, previously extensive frequency planning was performed to avoid the input signal from coinciding with these harmonic bins. More importance has been given to digital calibration in recent years where algorithms are developed and implemented outside ADC in a Digital signal processor (DSP), whereas the compensation is done in real time. In this work, we model the distortions and the harmonics present in the TI ADC output to get a clear understanding of the TI ADC. A post-correction block is developed for the cancellation of the characterized harmonics. The suggested method is tested on the TI ADCs working at radio frequencies, but is valid also for other types of ADCs, such as pipeline ADCs and sigma-delta ADCs.