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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
1

An attempt to establish an osteoporotic animal model.

January 2000 (has links)
Siu Wing Sum. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (leaves 135-150). / Abstracts in English and Chinese. / ABSTRACT (ENGLISH VERSION) --- p.i / ABSTRACT (CHINESE VERSION) --- p.v / ACKNOWLEDGEMENT --- p.viii / TABLE OF CONTENTS --- p.ix / LIST OF TABLES --- p.xiii / LIST OF FIGURES --- p.xv / LIST OF ABBREVIATIONS --- p.xix / Chapter CHAPTER 1: --- INTRODUCTION --- p.1 / Chapter 1.1 --- Epidemiology of Osteoporosis --- p.2 / Chapter 1.1.1 --- Prevalence and social aspects of osteoporosis --- p.2 / Chapter 1.1.2 --- Osteoporotic bone fracture --- p.2 / Chapter 1.1.3 --- Difficulties on fixation of osteoporotic bone fracture --- p.4 / Chapter 1.2 --- Physiology of osteoporotic bone --- p.5 / Chapter 1.2.1 --- Composition --- p.5 / Chapter 1.2.2 --- Architecture --- p.5 / Chapter 1.2.3 --- Bone remodelling --- p.7 / Chapter 1.3 --- Method to develop osteoporotic animal models --- p.9 / Chapter 1.3.1 --- Requirements for an ideal animal model --- p.9 / Chapter 1.3.2 --- Common animal models --- p.9 / Chapter 1.3.2.1 --- "Rodents, guinea pigs and rabbits" --- p.9 / Chapter 1.3.2.2 --- Non-human primates --- p.10 / Chapter 1.3.2.3 --- Dogs and pigs --- p.11 / Chapter 1.3.2.4 --- Sheep and goats --- p.12 / Chapter 1.3.3 --- Ovariectomy --- p.13 / Chapter 1.3.4 --- Restricted calcium diet --- p.17 / Chapter 1.4 --- Assessment of osteoporosis development --- p.18 / Chapter 1.4.1 --- Photo densitometry --- p.18 / Chapter 1.4.2 --- Bone densitometry by using Peripheral Quantitative Computed Tomography (pQCT) --- p.19 / Chapter 1.4.3 --- Biomechanics of osteoporotic bone --- p.21 / Chapter 1.4.3.1 --- Screw pullout test --- p.22 / Chapter 1.4.3.2 --- Indentation test --- p.22 / Chapter 1.4.4 --- Biochemical markers of bone turnover --- p.23 / Chapter 1.4.4.1 --- Bone formation markers --- p.24 / Chapter 1.4.4.1.1 --- Bone-specific Alkaline Phosphatase (BALP) --- p.25 / Chapter 1.4.4.1.2 --- Osteocalcin (OC) --- p.26 / Chapter 1.4.4.2 --- Bone resorption markers --- p.27 / Chapter 1.4.4.2.1 --- Deoxypyridinoline (Dpd) --- p.28 / Chapter 1.4.4.2.2 --- Creatinine --- p.29 / Chapter 1.5 --- Objectives --- p.30 / Chapter CHAPTER 2: --- METHODOLOGY --- p.32 / Chapter 2.1 --- Establishment of osteoporotic animal model --- p.32 / Chapter 2.1.1 --- Animal arrangement --- p.32 / Chapter 2.1.2 --- Ovariectomy --- p.34 / Chapter 2.1.3 --- Restricted calcium diet --- p.36 / Chapter 2.1.4 --- Confirmation of successful ovariectomy --- p.36 / Chapter 2.1.4.1 --- Histological assessment --- p.36 / Chapter 2.1.4.2 --- Biochemcial assessment --- p.37 / Chapter 2.2 --- Assessment of osteopenia development --- p.38 / Chapter 2.2.1 --- Photodensitometry --- p.39 / Chapter 2.2.1.1 --- Radiography --- p.39 / Chapter 2.2.1.2 --- Microradiograpgy --- p.39 / Chapter 2.2.2 --- Bone mineral density (BMD) measurement --- p.41 / Chapter 2.2.2.1 --- Iliac crest biopsy --- p.41 / Chapter 2.2.2.2 --- Bone autopsy --- p.43 / Chapter 2.2.3 --- Biomechanical tests --- p.44 / Chapter 2.2.3.1 --- Screw insertion and pullout test --- p.45 / Chapter 2.2.3.1.1 --- Femora --- p.47 / Chapter 2.2.3.1.2 --- Tibiae --- p.48 / Chapter 2.2.3.1.3 --- Lumbar vertebrae --- p.59 / Chapter 2.2.3.2 --- Indentation test --- p.51 / Chapter 2.2.4 --- Biochemical markers measurement --- p.53 / Chapter 2.2.4.1 --- Blood collection --- p.53 / Chapter 2.2.4.2 --- Urine collection --- p.53 / Chapter 2.2.4.3 --- Bone-specific Alkaline Phosphatase (BALP) --- p.54 / Chapter 2.2.4.4 --- Osteocalcin (OC) --- p.55 / Chapter 2.2.4.4.1 --- Sample and reagent preparation --- p.55 / Chapter 2.2.4.4.2 --- Measurement --- p.56 / Chapter 2.2.4.5 --- Deoxypyridinoline (Dpd) and urine creatinine --- p.57 / Chapter 2.2.4.5.1 --- Sample and reagent preparation --- p.58 / Chapter 2.2.4.5.2 --- Measurement --- p.59 / Chapter 2.2.4.5.3 --- Standardization of urine concentration --- p.59 / Chapter 2.3 --- Statistical analysis --- p.60 / Chapter CHAPTER 3: --- RESULTS --- p.61 / Chapter 3.1 --- Animal distribution --- p.61 / Chapter 3.2 --- Confirmation of successful ovariectomy --- p.65 / Chapter 3.3 --- Assessments in skeletal mature goats (Part I) --- p.66 / Chapter 3.3.1 --- Estradiol (E2) assessment --- p.66 / Chapter 3.3.2 --- Photo densitometry --- p.68 / Chapter 3.3.2.1 --- Proximal metaphysis of tibia --- p.69 / Chapter 3.3.2.2 --- Calcaneum --- p.70 / Chapter 3.3.2.3 --- Iliac crest biopsy --- p.72 / Chapter 3.3.3 --- Bone mineral density (BMD) measurement - by peripheral Quantitative Computed Tomography (pQCT) --- p.72 / Chapter 3.3.3.1 --- Iliac crest biopsy --- p.74 / Chapter 3.3.3.2 --- Lumbar vertebrae autopsy --- p.76 / Chapter 3.3.3.3 --- Calcaneus and humeral heads autopsy --- p.78 / Chapter 3.3.4 --- Biomechanical tests --- p.80 / Chapter 3.3.4.1 --- Screw pullout test --- p.80 / Chapter 3.3.4.2 --- Indentation test --- p.84 / Chapter 3.3.5 --- Biochemical markers --- p.86 / Chapter 3.3.5.1 --- Bone formation markers --- p.86 / Chapter 3.3.5.1.1 --- Bone-specific alkaline phosphatase (BALP) --- p.86 / Chapter 3.3.5.1.2 --- Osteocalcin (〇C) --- p.88 / Chapter 3.3.5.2 --- Bone resorption marker 226}0ؤ Deoxypyridinoline (Dpd) --- p.90 / Chapter 3.4 --- Assessments in skeletal immature goats (Part II) --- p.92 / Chapter 3.4.1 --- Estradiol (E2) assessment --- p.92 / Chapter 3.4.2 --- Bone mineral density (BMD) measurement - by peripheral Quantitative Computed Tomography (pQCT) --- p.94 / Chapter 3.4.2.1 --- Iliac crest biopsy --- p.94 / Chapter 3.4.2.2 --- "Lumbar vertebra, calcaneum and humeral head autopsy" --- p.94 / Chapter 3.4.3 --- Biomechanical tests --- p.98 / Chapter 3.4.3.1 --- Screw pullout test --- p.98 / Chapter 3.4.3.2 --- Indentation test --- p.102 / Chapter 3.4.4 --- Biochemical markers --- p.104 / Chapter 3.4.4.1 --- Bone formation markers --- p.104 / Chapter 3.4.4.1.1 --- Bone-specific alkaline phosphatase (BALP) --- p.104 / Chapter 3.4.4.1.2 --- Osteocalcin (〇C) --- p.104 / Chapter 3.4.4.2 --- Bone resorption marker 226}0ؤ Deoxypyridinoline (Dpd) --- p.107 / Chapter CHAPTER 4: --- DISCUSSION --- p.109 / Chapter 4.1 --- Experiences from other osteoporotic animal models --- p.110 / Chapter 4.2 --- OVARIECTOMIZED SKELETAL MATURE GOATS FED WITH LOW CALCIUM DIET suffered from osteopenia --- p.111 / Chapter 4.3 --- "Technique of ovariectomy, calcium content in diet and skeletal maturity are the determinants of the successful establishment of osteopenic goat model" --- p.120 / Chapter 4.4 --- Bone mineral density (BMD) measurement of the iliac crest biopsy by PERIPHERAL QUANTITATIVE COMPUTER TOMOGRAPHY (PQCT) IS THE BEST PARAMETER FOR THE ASSESSMENT OF OSTEOPENIA IN LIVING GOATS --- p.122 / Chapter 4.5 --- Further improvement of densitometric measurement --- p.123 / Chapter 4.6 --- Limitations of the present study --- p.125 / Chapter 4.7 --- Further studies --- p.129 / Chapter CHAPTER 5: --- CONCLUSION --- p.132 / Chapter CHAPTER 6: --- BIBLIOGRAPHY --- p.135
2

Improving decoding in intracortical brain-machine interfaces

Stetner, Michael E. January 2009 (has links)
Thesis (M.S.)--Case Western Reserve University, 2010. / [School of Medicine] Department of Biomedical Engineering. Includes bibliographical references.
3

Phenotyping rodents models of obesity using magnetic resonance imaging

Johnson, David Herbert. January 2009 (has links)
Thesis (Ph. D.)--Case Western Reserve University, 2009. / [School of Medicine] Department of Biology. Includes bibliographical references.
4

Image-guided high intensity focused ultrasound treatment for uterine leiomyomata /

Chan, Arthur Ho-Yin. January 2003 (has links)
Thesis (Ph. D.)--University of Washington, 2003. / Vita. Includes bibliographical references (leaves 286-298).
5

Trichomonas foetus infection and immunity in rabbits /

Byrne, Harold James. January 1942 (has links)
Thesis (Ph. D.)--University of Wisconsin, 1942. / Typescript (carbon copy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves [36-40]).
6

P2Y₂ nucleotide receptor up-regulation and function in submandibular gland epithelium

Schrader-Ratchford, Ann Marie. January 2005 (has links)
Thesis (Ph. D.)--University of Missouri-Columbia, 2005. / The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Vita. "May 2005" Includes bibliographical references.
7

Contraction-induced muscle damage in dogs with golden retriever muscular dystrophy /

Childers, Martin K. January 2002 (has links)
Thesis (Ph. D.)--University of Missouri--Columbia, 2002. / "December 2002." Typescript. Vita. Includes bibliographical references (leaves 141-160). Also issued on the Internet.
8

Exploring brain gene expression i animal models of behaviour /

Lindberg, Julia, January 2007 (has links)
Diss. (sammanfattning) Uppsala : Uppsala universitet, 2007. / Härtill 5 uppsatser.
9

A novel neuroprotective role for the Fas molecule in models of Parkinson's disease

Landau, Anne M. January 1900 (has links)
Thesis (Ph.D.). / Written for the Dept. of Physiology. Title from title page of PDF (viewed 2008/01/17). Includes bibliographical references.
10

Public health implications of the 1540 nm laser on the cornea /

McPherson, Nicole A. January 2007 (has links) (PDF)
Thesis (Ph. D.)--Uniformed Services University of the Health Sciences, 2007. / Typescript (photocopy).

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