Thesis (M.S.)--University of Michigan, Ann Arbor, 1974. / Typescript (photocopy). eContent provider-neutral record in process. Description based on print version record. Includes bibliographical references (leaves 34-36).

Thesis (M.S.)--University of Michigan, 1953. / eContent provider-neutral record in process. Description based on print version record.

Thesis (doctoral)--Katholieke Universiteit te Nijmegen, 1988. / Bibliography: p. 177-183.

Thesis (M.S.)--University of Michigan, 1952.

Thesis (M.S.)--University of Michigan, 1986.

Thesis (M.S.)--West Virginia University, 2004. / Title from document title page. Document formatted into pages; contains vii, 47 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 30-31).

Background and hypothesis. Edentulous patients may be at risk for malnutrition and cardiovascular disease even with well made dentures. Improvements in methods used to assess nutritional status suggest that functional biomarkers such as plasma homocysteine (tHcy), in addition to traditional methods, will provide a better quality assessment. The hypothesis is that there is an association between functional biomarkers of nutritional status and traditional cardiovascular disease risk factors in a community dwelling edentulous elderly population. / Methods. This was a cross-sectional study of the baseline characteristics of a convenient sample of 254 edentulous community dwelling elderly over 65 years. Measurements included anthropometric, body composition, homocysteine, vitamins and relevant blood components. Correlations, multiple regression models and Adjusted Odds Ratios (AOR) for tertiles were used to assess the relationship between vitamins and other parameters with hyperhomocystenemia, defined as THcy value of ≥ 14mmol/L. The independent effect of edentulism on hyperhomocysteinemia was sought using the NHANES III data. / Results. The prevalence of hyperhomocysteinemia was 49.2%. Effect of folate on hyperhomocysteinemia was significant (p = 0.037). Low folate tertile group had a 2.45 times higher odds (CI: 1.23, 4.87) of hyperhomocysteinemia than patients in the higher tertile (p = 0.019). Groups with normal folate did not have higher odds of hyperhomocysteinemia regardless of levels of vitamin B6 or B12. AOR for vitamin B12 tertiles in relation to hyperhomocysteinemia were 2.36 (CI: 1.18, 4.75) and 2.12 (1.07, 4.22) for lower vs. high. A weak inverse relationship existed between tHcy and vitamin C (r= -0.11, p= 0.045). A borderline negative correlation existed between HDL and THcy adjusted for age (r = - 0.12; P = 0.05). Significant correlation existed between THcy and BMI (r = 0.15, P = 0.02), small waist circumference (r = 0.22; p = 0.0004) and waist/hip ratio (r = 0.23, p = 0.0003). In a multivariate analyses, edentulism was associated with hyperhomocysteinemia (p = 0.012). / Conclusions. In this sample, homocysteine levels appeared much higher than one would expect with folate fortification, and were related to several cardiovascular risk factors. Using data from NHANES III, edentulism was found to independently predict hyperhomocysteinemia. The inverse relationship between homocysteine and vitamin C and the effect of folate on hyperhomocysteinemia suggests that increasing dietary intake of fruit and vegetables in edentulous individuals might be beneficial. Furthermore, the latter are at risk of developing hyperhomocysteinemia, a condition associated with cognitive impairment, dementia and coronary artery disease risk.

Thesis (M.S.)--University of Michigan, 1951.

No description available.

A necessidade do uso da prótese total durante o sono ainda não está bem definida pela literatura, apenas algumas evidências sobre a relação entre a presença de estomatite protética e o uso contínuo das próteses. O objetivo do estudo clínico randomizado foi avaliar se o uso da prótese total durante o sono interfere ou não nos eventos obstrutivos respiratórios durante o sono. Pacientes idosos edentulos com suspeita de Síndrome da Apnéia-hipopnéia Obstrutiva do Sono (SAOS) foram selecionados. Novas próteses totais foram confeccionadas seguindo o protocolo da FOUSP. A cavidade oral foi avaliada com relação ao exame de Mallampati e a presença de reabsorção óssea. A qualidade do sono foi avaliada pelo PSQI (Pittsburgh Sleep Quality Index) e pela Escala de Sonolência Diurna de Epworth (ESS), as polissonografias foram efetuadas em laboratório especializados durante duas noites em duas situações cruzadas: pacientes dormindo com as próteses e sem as mesmas. Vinte e três pacientes foram avaliados e a média de idade foi de 69,6 ± 5,1 anos e 74% eram do sexo feminino. Os pacientes com severidade leve, apresentaram um índice de apnéia-hipopnéia (IAH) significantemente menor quando os dormiram sem as próteses totais (8,9 ± 2,4 eventos por hora) comparado quando dormiram com as próteses (16,6 ± 6,9 eventos por hora). Os pacientes do grupo moderado a severo, não apresentaram diferença estatisticamente significante entre os IAHs quando dormiram com e sem as próteses. Em uma avaliação separada na posição supina, os pacientes do grupo leve, apresentaram uma média do IAH na posição supina menor quando dormiram sem as próteses do que quando dormiram com elas, apresentando uma média de 12,7 ± 8,4 eventos por hora e 51,9 ± 28,6 eventos por hora respectivamente. Pode-se concluir que os pacientes edentulos com severidade leve de SAOS apresentaram um menor índice de apnéia-hipopnéia obstrutiva quando dormiram na posição supina sem as próteses totais. / Summary: There is no evidence based in the literature about complete denture use during sleep, only some evidences about denture stomatits association and the change in apneic events. The goal of this randomized clinical study was to asses if the complete denture wear during sleep influence apneic events and quality of sleep. Elderly edentulous Obstructive Sleep Apnea Syndrome (OSAS) patients from a complete denture clinic were enrolled and received new complete dentures. The oral condition was evaluated according to bone resorption and Mallampati exam. The sleep quality was assed by the Pittsburgh Sleep Quality Index, the Epworth Sleepiness Scale and the polysomnographys were performed at the sleep laboratory for the patients sleeping with and without dentures the dentures. Twenty-three patients were evaluated with mean age 69.6 (SD±5.1) years and 74% female. In the mild (5AHI<30) OSAS group the apnea-hypopnea index decreased significantly when patients slept without dentures (8.9±2.4) compared when patients slept with the dentures (16.6±6.9). In a separated analysis, mild group in supine position presented a mean apnea-hypopnea index significant lower when patients slept without dentures from 12.7 (SD ± 8.4) to 51.9 (SD ± 28.6) sleeping with dentures. There was no significant difference in moderate to severe patients variables. This study shows that mild OSAS edentulous patients had a lower apnea-hypopnea index when sleeping without dentures in supine position.