High-fidelity CFD-MBD FSI (Computational Fluid Dynamics - Multi Body Dynamics Fluid-Structure Interaction) code development and validation by full-scale experiments is presented, for a novel hull form, WAM-V (Wave Adaptive Modular Vessel). FSI validation experiments include cylinder drop with suspended mass and 33 ft WAM-V sea-trials. Calm water and single-wave sea-trails were with the original suspension, while the rough-water testing was with a second generation suspension. CFDShip-Iowa is used as CFD solver, and is coupled to Matlab Simulink MBD models for cylinder drop and second generation WAM-V suspension. For 1DOF cylinder drop, CFD verification and validation (V&V) studies are carried out including grid and time-step convergence. CFD-MBD results for 2DOF cylinder drop show that 2-way coupling is required to capture coupled physics. Overall, 2-way results are validated with an overall average error value of E=5.6%DR for 2DOF cylinder drop. For WAM-V in calm water, CFD-MBD 2-way results for relative pod angle are validated with E=14.2%DR. For single-wave, CFD-MBD results show that 2-way coupling significantly improves the prediction of the peak amplitude in pontoon motions, while the trough amplitudes in suspension motions are under-predicted. The current CFD-MBD 2-way results for single-wave are validated with E=17%DR. For rough-water, simulations are carried out in regular head waves representative of the irregular seas. CFD-MBD 2-way results are validation with E=23%D for statistical values and the Fourier analysis results, which is reasonable given the differences between simulation waves and experiments.