Yes / Owing to the high specific energy consumption associated with thermal desalination technologies such as Multi Effect Distillation (MED), there is a wide interest to develop a cost-effective desalination technology. This study focuses on improving the operational, economic, and environmental perspectives of hybrid MED-TVC (thermal vapour compression) process via optimisation. Application of particle swarm optimisation (PSO) in several engineering disciplines have been noted but its potential has not been exploited fully in desalination technologies especially MED-TVC in the past. A multi-objective non-linear optimisation framework based on PSO is constructed here. Two of our earlier models have been used to predict the key process performance and cost indicators. The models are embedded within the PSO optimisation algorithm to develop a new hybrid optimisation model which minimises the total freshwater production cost, total specific energy consumption and brine flow rate while maintaining a fixed freshwater production for a given number of effects and seawater conditions. The steam flow rate and temperature are considered as control variables of the optimisation problem to achieve the objective function. The PSO has successfully achieved the optimum indexes for the hybrid MED-TVC process for a wide range of number of effects. It also shows a maximum reduction of freshwater production cost by 36.5%, a maximum energy saving by 32.1% and a maximum reduction of brine flow rate by 38.3%, while maintaining the productivity of freshwater.