<p dir="ltr">Progress in deep learning methodologies has transformed the landscape of medical image analysis, opening fresh pathways for precise and effective diagnostics. Currently, multi-phase liver CT scans follow a four-stage process, commencing with an initial scan carried out before the administration of <a href="" target="_blank">intravenous (IV) contrast-enhancing material</a>. Subsequently, three additional scans are performed following the contrast injection. The primary objective of this research is to automate the analysis and prediction of 50% of liver CT scans. It concentrates on discerning patterns of intensity change during the second, third, and fourth phases concerning the initial phase. The thesis comprises two key sections. The first section employs the non-contrast phase (first scan), late hepatic arterial phase (second scan), and portal venous phase (third scan) to predict the delayed phase (fourth scan). In the second section, the non-contrast phase and late hepatic arterial phase are utilized to predict both the portal venous and delayed phases. The study evaluates the performance of two deep learning models, U-Net and U²-Net. The process involves preprocessing steps like subtraction and normalization to compute contrast difference images, followed by post-processing techniques to generate the predicted 2D CT scans. Post-processing steps have similar techniques as in preprocessing but are performed in reverse order. Four fundamental evaluation metrics, including <a href="" target="_blank">Mean Absolute Error (MAE), Signal-to-Reconstruction Error Ratio (SRE), Peak Signal-to-Noise Ratio (PSNR), and Structural Similarity Index Measure (SSIM), </a>are employed for assessment. Based on these evaluation metrics, U²-Net performed better than U-Net for the prediction of both portal venous (third) and delayed (fourth) phases. Specifically, U²-Net exhibited superior MAE and PSNR results for the predicted third and fourth scans. However, U-Net did show slightly better SRE and SSIM performance in the predicted scans. On the other hand, for the exclusive prediction of the fourth scan, U-Net outperforms U²-Net in all four evaluation metrics. This implementation shows promising results which will eliminate the need for additional CT scans and reduce patients’ exposure to harmful radiation. Predicting 50% of liver CT volumes will reduce exposure to harmful radiation by half. The proposed method is not limited to liver CT scans and can be applied to various other multi-phase medical imaging techniques, including multi-phase CT angiography, multi-phase renal CT, contrast-enhanced breast MRI, and more.</p>