Multiple sclerosis is thought to be an autoimmune disease that causes lesions and demyelination of axons in the central nervous system. A reduction in relapses is seen in the third trimester of pregnancy when estrogen levels are highest, followed by an increase in relapses in the first three months post-partum when estrogen levels drop. This thesis focuses on the effect of 17beta- and 17alpha-estradiol on myelination and remyelination in cultured rat cerebellar slices. No reproducible effect of 17beta-estradiol on myelination was detected. However, during lysolecithin-induced demyelination it had a possible protective effect in males and females, although it was not statistically significant. During myelination, 100 nM 17alpha-estradiol caused a small but significant decrease in MBP expression in females. During lysolecithin-induced demyelination, it had a possible, but not statistically significant, protective effect in males. Neither 17beta- nor 17alpha-estradiol had a reproducible or significant effect on remyelination in males or females.

Multiple sclerosis is thought to be an autoimmune disease that causes lesions and demyelination of axons in the central nervous system. A reduction in relapses is seen in the third trimester of pregnancy when estrogen levels are highest, followed by an increase in relapses in the first three months post-partum when estrogen levels drop. This thesis focuses on the effect of 17beta- and 17alpha-estradiol on myelination and remyelination in cultured rat cerebellar slices. No reproducible effect of 17beta-estradiol on myelination was detected. However, during lysolecithin-induced demyelination it had a possible protective effect in males and females, although it was not statistically significant. During myelination, 100 nM 17alpha-estradiol caused a small but significant decrease in MBP expression in females. During lysolecithin-induced demyelination, it had a possible, but not statistically significant, protective effect in males. Neither 17beta- nor 17alpha-estradiol had a reproducible or significant effect on remyelination in males or females.

Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 112-122).

Thesis (M.Sc.)--University of Western Sydney, Nepean, 1995. / Includes bibliography.

Thesis (BA(Hons) (Psychology)) - Faculty of Life and Social Sciences, Swinburne University of Technology, 2006. / "October 2006". A thesis is submitted in fulfillment of the requirements for the degree Bachelor of Arts (Honours), [Faculty of Life and Social Sciences], Swinburne University of Technology - 2006. Typescript.

Thesis (Ph.D.)--Virginia Commonwealth University, 2008. / Prepared for: Dept. of Biochemistry. Title from title-page of electronic thesis. Bibliography: leaves 141 - 176.

Thesis (Ed.D.)--Teachers College, Columbia University, 1992. / Includes tables. Typescript; issued also on microfilm. Sponsor: Victoria J. Marsick. Dissertation Committee: Jack Mezirow. Includes bibliographical references (leaves 199-209).

Thesis (Ed.D.)--Teachers College, Columbia University, 1992. / Includes tables. Typescript; issued also on microfilm. Sponsor: Marilyn Rawnsley. Dissertation Committee: Debra Noumair. Includes bibliographical references (leaves 127-141).

Thesis (M.Sc.). / Written for the School of Physical and Occupational Therapy. Title from title page of PDF (viewed 2009/06/18). Includes bibliographical references.

Thesis (doctoral)--Groningen, 1980.